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Dr. András Perczel D.Sc., Corresponding member of HAS, full professor

Address: 1518 Budapest 112, Pf.: 32, Hungary

Room: 427/A

Email:

Phone: +36 (1) 372-2500 / 1653

Fax: +36 (1) 372-2620

Born At: May 10, 1959

Studies

  • 1973-1977: Roman Catholic High-school of Piarists
  • 1980-1981: Technical University (Veszprém/Hungary)
  • 1982-1985: Eötvös Loránd University (Budapest / Hungary) M.Sc. Chemistry major (1136/1985)
  • 1989: Ph.D. "Synthesis and conformational analysis of peptides and glycopeptides” (ELTE/Budapest; ELTE D-285/1988)
  • 1993: C.Sd. „Synthesis and conformational analysis of peptides and peptide derivatives via synthetic, computational and spectroscopic methods” (HAS-14337)
  • 1998: D.Sc. "Modelling secondary structural elements of proteins via synthetic, spectroscopic and computational methods" (HAS-3660)
  • 1999: Habilitation (ELTE 210/1999)
  • 2010: Member of the Hungarian Academy of Sciences
  • 2012: Member of The Academy of Europe

Posts Held

  • 2007- 2010 Head of the Department of Organic Chemistry, Inst. Of Chemistry, ELTE
  • 2001- Professor at the Dep. of Chemistry, Inst. Of Chemistry, ELTE
  • 1998-2001: Research Professor at the Dep. of Chem., Inst. Of Chemistry, ELTE 
  • 1997-1998: Research associate prof. at the Dep. of Chem., Inst. Of Chemistry, ELTE
  • 1995-1997: Research fellow, Dep. of Biochemistry, Oxford Univ., UK
  • 1993-1995: Research associate at the Dep. of Chem., Inst. Of Chemistry, ELTE
  • 1992-1994: NSERC. Post doc. Fellow at the Dep. of Chem., Univ. of Toronto, Canada
  • 1989-1992: Post. Doc. Fellow at the Dep. of Biochemistry, Brandeis Univ., Massachusetts USA
  • 1985-1988: Fellow of the Hungarian Academy of Sciences (PhD student)

Actual courses

  • 2012-13/II Organic chemistry for biologists (lectures: kv1c1bk1) 14*4 h (Monday/0.65 14.00-16.00, Wednesday/0.65 12.00-14.00)
  • 2012-13/II Biological chemistry (lectures: kb1n1202) 14*3 h (Thursday/-1.75 8.00-11.00)
  • 2012-13/II Structure and Dynamics of Proteins and peptides via spectroscopic methods (special courses: kv2n9o35) 14*2 h

Teaching experiences

organic chemistry courses and practicals, special courses in bio-spectroscopy
various graduate, post-graduate lecture courses in structural chem.
supervision of two dozens of graduate and D.Phil. students

details:

  • 2011- BioNMR spectroscopy (special course and practicals) 14*(2+3) h./semester I
  • 2009- Biological chemistry (lectures) 14*4 h./semester II
  • 2003-08 Theoretical organic chemistry (lectures) 14*2 h./semester I
  • 2008- Natural products (lectures biology major) 14*3 h./semester I for
  • 2001- Organic chemistry (lectures for biology major) 14*4 h./semester II
  • 1997- NMR pulse sequences in structure determination (special course) 14*2h./semester I
  • 1994- Structural investigation of peptides and proteins (special course) 14*2h./semester II
  • 1985-88, 1993-95, 1996-2001 Organic chemistry (laboratory course) 14*6 h./semester

Students

Research

  • Synthesis of peptides on solid phase and using biotechnology
  • Spectroscopic analysis (CD, NMR) of bioactive peptides
  • Structure and stability of α- and β-peptides, foldamers and their nanofibril-formation and aggregation properties
  • BioNMR of protein : structure, dynamics and function of globular and disordered (IDP) systems
  • Mapping protein-ligand interactions, structural investigations of biologically important systems (enzymes, receptors, etc.)

Research experiences

  • Prof. R.Daudel (Pierre et Marie Curie, Sorbon, Paris, France 1989)
  • Prof. G.D.Fasman (Brandeis, Boston, USA 1989-1992)
  • Prof. H.H.Mantsch (NRC Ottawa, Canada 1991)
  • Prof. I.G.Csizmadia (Univ. of Toronto, Canada 1991, 1992-1994)
  • Prof. I.D.Campbell (Univ. of Oxford, UK 1994, 1995-1997, 1998) FEBS researcher
  • Prof. J. Markley (Univ. Of Madison, USA, 2006), Fulbright fellow

Publications

Publications: Over 250 peer reviewed articles, over 3000 citations of non-collaborating authors,
with a cumulative IF of >550; H-index=35

Grants: Hungarian Research Foundation OTKA (6), Grant form the Hungarian Ministry of Education and Culture (4), Welcome Foundation Grant (2), ICGEB-UNESCO (2), East-NMR (FP7), COST(1)

Prime Publications

  • Klára Z. Gerlei , Imre Jákli , Milán Szőri , Svend J. Knak Jensen , Béla Viskolcz , Imre G. Csizmadia , András Perczel
    Atropisomerism of the Asn α Radicals Revealed by Ramachandran Surface Topology.
    J. Phys. Chem. B 117(41):12402-12409. | DOI: 10.1021/jp4070906 | PMID: 24015919 (2013) Kivonat
  • Orsolya Barabás , Vince I. Grolmusz , Zoltán Szabadka , Imre Zagyva , Zoltán Kele , Edina Rosta , András Perczel , Andrea Bodor , Veronika Németh , Matthias Wilmanns
    Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, <sup>31</sup>P-NMR spectroscopy and reaction path modelling
    Nucleic Acids Res. DOI: 10.1093/nar/gkt756 | PMID: 23982515 (2013) Kivonat
  • Adriana D. Garro , Ana M. Rodríguez , Javier López Cascales , Botond Penke , Csaba Somlai , András Perczel , Gabriela Feresin , Alejandro Tapia , Beatriz Lima , José A. Bombasaro , Mónica S. Olivella , Ricardo D. Enriz
    Penetratin and derivatives acting as antibacterial agents
    Chem. Biol. Drug. Des. 82(2):167-177. | DOI: 10.1111/cbdd.12143 | PMID: 23581817 (2013) Kivonat
  • Gábor Pohl , Esther Gorrea , Vicenç Branchadell , Rosa M. Ortuño , András Perczel , György Tarczay
    Foldamers of β-peptides: conformational preference of peptides formed by rigid building blocks. The first MI-IR spectra of a triamide nanosystem.
    Amino Acids 45(4):957-973. | DOI: 10.1007/s00726-013-1552-7 | PMID: 23860847 (2013) Kivonat
  • Imre Jákli , Szilárd N. Fejér , Ödön Farkas , Béla Viskolcz , Svend J. Knak Jensen , Imre G. Csizmadia , András Perczel
    Helix compactness and stability: Electron structure calculations of conformer
    Chem. Phys. Lett. 563:80-87. (2013) Kivonat

List of Publications

Awards

  • Scientist of the year, Pest County, 2012
  • Elected member of Science Europea , 2012
  • Bolyai Prize, perhaps the highest scientific award in Hungary, 2011
  • Elected member of the Hungarian Academy of Sciences , 2010
  • Fulbright fellow, 2006
  • Scientist of the year, Sanofi-Synthelabo, 2004
  • Széchényi Professor (1998-2002)
  • Scientific award (1st price), 1997 (form the Faculty of Science L. Eötvös. Univ.)
  • Zemplén Géza junior award, 1996 ( form the Hungarian Acad. of Sci.)
  • Pro Scientia gold medal, 1993 and 1995 (form HAS)