Using both classical organic chemistry and modern bacterial expression systems we synthesize polypeptides, foldamers and proteins of various size and biological significance. Structure elucidation and internal dynamics of biomolecules are completed by X-ray and bioNMR spectroscopy, as well as molecular modeling, applied quantum chemistry and bioinformatics. We do cooperate with both Hungarian and foreign research teams on subjects ranging from organic chemistry to molecular biology. Recently we are synthesizing amino acids derived form carbohydrates, determining conformational properties of beta amino acids, synthesizing foldamers, expressing Exenatide-4 analogs used to treat type II Diabetes Mellitus, and conducting research for a better understanding Alzheimer’s and other conformational diseases, etc…Devoted students and people interested in modern structural chemistry and biology are always welcome.
New building blocks synthesized: just published in Amino Acids
„C-3 epimers of sugar amino acids as foldameric building blocks: improved synthesis, useful derivatives, coupling strategies”. Yield optimized, scalable and environment-friendly protocols for making β-sugar amino acids and their derivatives to built up α/β-chimera peptides.
A new cover story from our lab.
Our paper ,,Aromatic cluster sensor of protein folding: near-UV ECD bands assigned to fold compactness" accepted as a Hot Paper in Chemistry- a European Journal shows that both Tyr and Trp ECD bands could be used as 3D-fold sensors, applicable for many more proteins.
- Older news
Beáta Biri-Kovács , Bence Kiss , Henrietta Vadászi , Gergő Gógl , Gyula Pálfy , György Török , László Homolya , Andrea Bodor , László Nyitray
Ezrin interacts with S100A4 via both its N- and C-terminal domains
PLoS One 12(5):e0177489 | doi: 10.1371/journal.pone.0177489 | PMID: 28493957 (2017) Kivonat
Adrienn Nagy , Barbara Csordás , Virág Zsoldos-Mády , István Pintér , Viktor Farkas , András Perczel
C‐3 epimers of sugar amino acids as foldameric building blocks: improved synthesis, useful derivatives, coupling strategies
Amino Acids 49(2):223–240. DOI: 10.1007/s00726-016-2346-5 | PMID: 27803987 (2017) Kivonat
Tibor Szénási , Judit Oláh , Adél Szabó , Sándor Szunyogh , András Láng , András Perczel , Attila Lehotzky , Vladimir N. Uversky , Judit Ovádi
Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins
Biochim Biophys Acta - Molecular Basis of Disease 1863(1):310-323. DOI: 10.1016/j.bbadis.2016.09.017. | PMID: 27671864 (2017) Kivonat
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