in spectra

NMR, ECD,

VCD, FTIR,..

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in crystal

 X-ray diffraction,

crystallography,...

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in silico

bio-informatics, applied QM,

molecular modeling,...

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in vivo/in vitro

biotechnology, protein production, 

preparative work, classical synthesis,..

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Dsc 0059 1

Using both classical organic chemistry and modern bacterial expression systems we synthesize polypeptides, foldamers and proteins of various size and biological significance. Structure elucidation and internal dynamics of biomolecules are completed by X-ray and bioNMR spectroscopy, as well as molecular modeling, applied quantum chemistry and bioinformatics. We do cooperate with both Hungarian and foreign research teams on subjects ranging from organic chemistry to molecular biology. Recently we are synthesizing amino acids derived form carbohydrates, determining conformational properties of beta amino acids, synthesizing foldamers, expressing Exenatide-4 analogs used to treat type II Diabetes Mellitus, and conducting research for a better understanding Alzheimer’s and other conformational diseases, etc…Devoted students and people interested in modern structural chemistry and biology are always welcome. P1030653

Csoport 1

News

  • New building blocks synthesized: just published in Amino Acids

    „C-3 epimers of sugar amino acids as foldameric building blocks: improved synthesis, useful derivatives, coupling strategies”. Yield optimized, scalable and environment-friendly protocols for making β-sugar amino acids and their derivatives to built up α/β-chimera peptides.

    Grap Abstr 1 Ap 1(1)

  • A new cover story from our lab.

    Our paper ,,Aromatic cluster sensor of protein folding: near-UV ECD bands assigned to fold compactness" accepted as a Hot Paper in Chemistry- a European Journal shows that both Tyr and Trp ECD bands could be used as 3D-fold sensors, applicable for many more proteins.

    Farkas 2016 Cover Doi

  • Older news

Recent Publications

  • Szebasztián Szaniszló , Imre G. Csizmadia , András Perczel
    How weak an acid can be? Variations of H-bond and/or van der Waals Interaction of Weak Acids
    Struct. Chem. 28(2):371-378. | DOI: 10.1007/s11224-016-0888-5 (2017) Kivonat
  • Dóra K. Menyhárd , Ilona Hudáky , Imre Jákli , György Juhász , András Perczel
    Predictable conformational diversity in foldamers of sugar amino acids
    J. Chem. Inf. Model. 57(4):757–768. DOI: 10.1021/acs.jcim.6b00488 (2017) Kivonat
  • Adrienn Nagy , Barbara Csordás , Virág Zsoldos-Mády , István Pintér , Viktor Farkas , András Perczel
    C‐3 epimers of sugar amino acids as foldameric building blocks: improved synthesis, useful derivatives, coupling strategies
    Amino Acids 49(2):223–240. DOI: 10.1007/s00726-016-2346-5 | PMID: 27803987 (2017) Kivonat
  • Tibor Szénási , Judit Oláh , Adél Szabó , Sándor Szunyogh , András Láng , András Perczel , Attila Lehotzky , Vladimir N. Uversky , Judit Ovádi
    Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins
    Biochim Biophys Acta - Molecular Basis of Disease 1863(1):310-323. DOI: 10.1016/j.bbadis.2016.09.017. | PMID: 27671864 (2017) Kivonat
  • András Perczel , Ricardo D. Enriz , Atanas G. Atanasov , Vladimír Sklenář , Jiří Nováček , Veronika Papoušková , Pavel Kadeřávek , Lukáš Žídek , Henryk Kozłowski , Joanna Wątły , Aleksandra Hecel , Paulina Kołkowska , Jaroslav Koča , Radka Svobodová-Vařeková , Lukáš Pravda , David Sehnal , Vladimír Horský , Stanislav Geidl , Pavel Matějka , Adéla Jeništová , Marcela Dendisová , Alžběta Kokaislová , Volkmar Weissig , Mark Olsen , Aidan Coffey , Jude Ajuebor , Ruth Keary , Marta Sanz-Gaitero , Mark J. van Raaij , Olivia McAuliffe , Birgit Waltenberger , Andrei Mocan , Karel Šmejkal , Elke H. Heiss , Marc Diederich , Robert Musioł , Janez Košmrlj , Jarosław Polański , Josef Jampílek
    The Eighth Central European Conference “Chemistry towards Biology”: Snapshot
    Molecules 21(10):1381 DOI:10.3390/molecules21101381 (2016) Kivonat
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