in spectra




in crystal

 X-ray diffraction,



in silico

bio-informatics, applied QM,

molecular modeling,...


in vivo/in vitro

biotechnology, protein production, 

preparative work, classical synthesis,..


Dsc 0059 1

Using both classical organic chemistry and modern bacterial expression systems we synthesize polypeptides, foldamers and proteins of various size and biological significance. Structure elucidation and internal dynamics of biomolecules are completed by X-ray and bioNMR spectroscopy, as well as molecular modeling, applied quantum chemistry and bioinformatics. We do cooperate with both Hungarian and foreign research teams on subjects ranging from organic chemistry to molecular biology. Recently we are synthesizing amino acids derived form carbohydrates, determining conformational properties of beta amino acids, synthesizing foldamers, expressing Exenatide-4 analogs used to treat type II Diabetes Mellitus, and conducting research for a better understanding Alzheimer’s and other conformational diseases, etc…Devoted students and people interested in modern structural chemistry and biology are always welcome. P1030653

Csoport 1


  • Approaches to Pyranuronic β-Sugar Amino Acid Building Blocks of Peptidosaccharide Foldamers

    Pyranuronic β-sugar amino acids (β-SAAs) are biocompatible and tuneable building blocks of foldamers and α/β chimera peptides. The scalable and economical total synthesis of two building blocks was described. These C-4 epimers, Fmoc-GlcAPU(Me)-OH and Fmoc-GalAPU(Me)-OH, which are suitable for solid phase peptide synthesis, were prepared via a common oxime intermediate. The new synthesis uses nine consecutive steps, starting from methyl α-D-glucopyranoside. The synthesis is fine-tuned, optimized, and ready for largescale and cost-efficient production.

    Eur. J. Org. Chem. 2018, 355

    Ejoc201701612 Toc 0001 M

  • New building blocks synthesized: just published in Amino Acids

    „C-3 epimers of sugar amino acids as foldameric building blocks: improved synthesis, useful derivatives, coupling strategies”. Yield optimized, scalable and environment-friendly protocols for making β-sugar amino acids and their derivatives to built up α/β-chimera peptides.

    Grap Abstr 1 Ap 1(1)

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Recent Publications

  • Anna Huber , Dorottya Hajdu , Doris Bratschun-Khan , Zoltán Gáspári , Mihayl Varbanov , Stéphanie Philippot , Ádám Fizil , András Czajlik , Zoltán Kele , Christoph Sonderegger , László Galgóczy , Andrea Bodor , Florentine Marx , Gyula Batta
    New Antimicrobial Potential and Structural Properties of PAFB: A Cationic, Cysteine-Rich Protein from Penicillium chrysogenum Q176
    Scientific Reports 8:1751. PMID: 29379111 | DOI:10.1038/s41598-018-20002-2 (2018) Kivonat
  • Viktória Goldschmidt Gőz , István Pintér , Veronika Harmat , András Perczel
    Approaches to Pyranuronic beta-Sugar Amino Acid Building Blocks of Peptidosaccharide Foldamers
    Eur. J. Org. Chem. 355-361. DOI: 10.1002/ejoc.201701612 (2018) Kivonat
  • Tamás Vajda , András Perczel
    The impact of water on the ambivalent behavior and paradoxical phenomenon of the amyloid-β fibril protein
    Biomol. Concepts 8(5-6):213-220. PMIID: 29211680 | DOI: 10.1515/bmc-2017-0027 (2017) Kivonat
  • Gergő Gógl , Beáta Biri-Kovács , Ádám L Póti , Henrietta Vadászi , Bálint Szeder , Andrea Bodor , Gitta Schlosser , András Ács , Lilla Turiák , László Buday , Anita Alexa , László Nyitray , Attila Reményi
    Dynamic control of RSK complexes by phosphoswitch-based regulation
    FEBS J 285:46-71. PMID: 29083550 | DOI: 10.1111/febs.14311 (2017) Kivonat
  • Ádám Sturm , András Perczel , Zoltán Ivics , Tibor Vellai
    The Piwi-piRNA pathway: road to immortality
    Aging Cell 16:906-911. PMID: 28653810 | DOI: 10.1111/acel.12630 (2017) Kivonat
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