Polymorphic amyloid nanostructures of hormone peptides involved in glucose homeostasis display reversible amyloid formation

Published October 17, 2023 10:58

A group of hormone peptides is stored in the form of functional amyloid fibers in acid secretion vesicles before they reassemble their biologically active helical spatial structure when they enter the blood circulation. In the article published in Nature Communications, we explain the molecular basis of pH-dependent reversible amyloid formation in the case of gastrointestinal peptides belonging to the glucagon family. The article is presented on the website of the MTA by several Hungarian online newspapers. [1, 2, 3]

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