We do cooperate with both Hungarian and foreign research teams on subjects ranging from organic chemistry to molecular biology. We run several ELTE-based, joint research projects, even at the national level, such as MedInProt, HunProtExc, or the SynthPlusz Excellence Programs. Recently we are synthesizing amino acids derived from carbohydrates, determining conformational properties of beta amino acids, synthesizing foldamers, expressing Exenatide-4 analogs used to treat type II Diabetes Mellitus, and conducting research for a better understanding Alzheimer’s and other conformational diseases. Furthermore, we work on the structure and dynamics of kRas signaling protein, which plays an important role in tumor diseases. Devoted students, postdocs and researchers interestedin modern structural chemistry and biology.
News
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Our new paper is out!
We have moved to a higher level! :)
We have published another communication on flow peptide chemistry. The synthesis of looonger polypeptides (58-76 aa.) has been achieved using an HPLC-based apparatus.
Keep calm and make SPF! ;)Synthesis of small protein domains by automated flow chemistry
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Design and Characterization of a Multistage Peptide-Based Vaccine Platform to Target Mycobacterium tuberculosis Infection
In our recent collaborative article, we described the design and development of an immunogenic, self-adjuvanting, multistage vaccine platform against Mycobacterium tuberculosis (Mtb), obtained by combining the synthesis of a multiepitope lipopeptide with chemoselective ligation.
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Amide isomerization pathways: Electronic and structural background of protonation- and deprotonation-mediated cis-trans interconversions
In this article a possible reaction route for the cis-trans isomerization of non-proline (Xxx-nonPro) peptide bonds is described via protonation using DFT and coupled cluster computational results.
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Recent Publications
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Szebasztián Szaniszló , Antal Csámpai , Dániel Horváth , Richárd Tomecz , Viktor Farkas , András Perczel
Unveiling the Oxazolidine Character of Pseudoproline Derivatives by Automated Flow Peptide Chemistry
International Journal of Molecular Sciences 25(8), 4150 I DOI: https://doi.org/10.3390/ijms25084150 (2024) Kivonat -
Karima Tarchoun , Dóra Soltész , Viktor Farkas , Ho-Jin Lee , Ildikó Szabó , Zoltán Bánóczi
Influence of Aza-Glycine Substitution on the Internalization of Penetratin
Pharmaceutics 16(4), 477 I DOI: https://doi.org/10.3390/pharmaceutics16040477 (2024) Kivonat -
Kristóf Ferentzi , Dóra Nagy-Fazekas , Viktor Farkas , András Perczel
Synthesis of small protein domains by automated flow chemistry
Reaction Chemistry & Engineering 9, 58-69 I DOI: https://doi.org/10.1039/D3RE00324H (2023) Kivonat -
Ádám A. Kelemen , András Perczel , Dániel Horváth , Imre Jákli
Amide isomerization pathways: Electronic and structural background of protonation- and deprotonation-mediated cis-trans interconversions
J. Chem. Phys. 159 (15): 154301. | DOI: https://doi.org/10.1063/5.0165772 (2023) Kivonat -
Chiara Bellini , Emil Vergara , Fruzsina Bencs , Kinga Fodor , Szilvia Bõsze , Denis Krivić , Bernadett Bacsa , Sára Eszter Surguta , József Tóvári , Rajko Reljic , Kata Horváti
Design and Characterization of a Multistage Peptide-Based Vaccine Platform to Target Mycobacterium tuberculosis Infection
Bioconjugate Chemistry 34(10): 1738–1753 (2023) Kivonat - More publications