Harmatv

Dr. Veronika Harmat Ph.D., assistant professor

Address: H-1117 Budapest, Pázmány Péter sétány 1/A

Room: 5.123

Email:

Phone: +36 (1) 372-2500 / 6547

Fax: +36 (1) 372-2592

Born At: April 24, 1973

Born In: Budapest

Lab: Protein crystallography lab.

Studies

  • 2003,   Ph.D. in Structural Chemistry, Eötvös Loránd University
  • 1996,   M.Sc. in chemistry Eötvös Loránd University

Posts Held

  • 2014, 2015, 2016 HAS, BRC, research fellow
  • 2008- assistant professor, Eötvös Loránd University
  • 2007- research fellow, Protein Modeling Group, HAS/ELTE
  • 2003-2006 junior research fellow, Protein Modeling Group, HAS/ELTE
  • 2001-2002  demonstrator, Eötvös Loránd University

Actual courses

  • X-ray crystallography lectures (in Chemistry M.Sc.)
  • Protein crystallography lectures (special courses for students inChemistry and Biology)
  • Modern methods for strucutral studies (X-ray crystallography, a part of the courses; in Chemistry M.Sc.)
  • General chemistry calculations practice (in Chemistry B.Sc.)
  • General chemistry laboratory practice (in Chemsitry and Biology B.Sc.)

Teaching experiences

  • 2011- Methods in protein crytallography, Ph.D. course
  • 2006- Protein crystallography, special course in Chemistry and Biology major
  • 1999- X-ray crystallography, semi-optional course in Chemistry
  • 2000- X-ray crystallography laboratory practice
  • 2001-2002, 2008- General chemistry laboratory practice (in Chemistry and Biology B.Sc.)
  • 2008- General chemistry calculations practice (in Chemistry B.Sc.)
  • 2009- Inorganic chemistry laboratory practice (in Earth Sciences B.Sc.)

Students

Research

Interest: Structural aspects of molecular recognition in protein action 

  • Serin proteases of the complement system (specificity, autocatalytic activity, regulation) (Cooperation: HAS RCNS Institute of Enzymology, Structural Biophysics group; ELTE Department of Biochemistry)
  • Acylpeptide hydrolases (specificity and quaterner strucutre) (Cooperation: HAS RCNS Institute of Enzymology, Proteases group)
  • Calmodulin/small molecule complexes (Cooperation: HAS RCNS Institute of Enzymology, Lysophospholipid receptors group)
  • Structure and function of dUTPases (Cooperation: HAS RCNS Institute of Enzymology, Genome metabolism group, Technical University, Budapest)

http://ttk.mta.hu      http://elte-biokemia.hu/index.php?pg=mnukutatas

Cooperation in protein crystallography: Biostruct laboratory (www.biostruct.org )

Publications

International scientific papers: 50
Hungarian scientific papers: 4
Book chapter, e-learning :1, 1
Patent application: 1
Impact factor: 165
All citations / independent citations: 948 / 639
H-index: 18

Prime Publications

  • Veronika Harmat , Klarissza Domokos , Dóra K. Menyhárd , Anna Palló , Zoltán Szeltner , Ilona Szamosi , Tamás Beke , Gábor Náray-Szabó , László Polgár
    Structure and catalysis of acylamonoacyl peptidase: closed and open subunits of a dimer oligopeptidase
    Journal of Biological Chemistry 286:1987-1998. PMID: 21084296 | DOI: 10.1074/jbc.M110.169862 (2011) Kivonat
  • József Dobó , Veronika Harmat , László Beinrohr , Edina Sebestyén , Péter Závodszky , Péter Gál
    MASP-1, a Promiscuous Complement Protease: Structure of Its Catalytic Region Reveals the Basis of Its Broad Specificity
    J. Immunol. 183:1207-1214. (2009) Kivonat
  • Dóra K. Menyhárd , Anna Kiss-Szemán , Éva Tichy-Rács , Balázs Hornung , Krisztina Rádi , Zoltán Szeltner , Klarissza Domokos , Ilona Szamosi , Gábor Náray-Szabó , László Polgár , Veronika Harmat
    A self-compartmentalizing hexamer serine protease from Pyrococcus horikoshii: substrate selection achieved through multimerization
    J Biol Chem 288(24):17884-17894. | DOI: 10.1074/jbc.M113.451534 | PMID: 23632025 (2013) Kivonat
  • László Beinrohr , Veronika Harmat , József Dobó , Zsolt Lörincz , Péter Gál , Péter Závodszky
    C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease
    J. Biol. Chem. 282: 21100-21109. (2007) Kivonat

List of Publications

Awards

  • 2006,   Young Scientist Award of the Hungarian Academy of Sciences
  • 2001-2004,   Bolyai János Research Fellowship