Published January 20, 2025 11:02
Pseudoproline derivatives, like Thr(ΨPro)-OH, are utilized in peptide synthesis to minimize peptide aggregation and aspartimide formation, but they may induce notable side reactions, particularly under elevated temperature and pressure.This study explores the oxazolidine moiety's behavior and proposes mechanisms to mitigate these side reactions, offering a thermodynamically controlled solution to aspartimide formation.
