Publications

2024

• Direct Continuous Flow Synthesis of Two Difficult Polypeptides Using β-Cyclodextrins

  Szebasztián Szaniszló , Gitta Schlosser , Viktor Farkas , András Perczel

  J. Org. Chem. (2024) DOI: https://doi.org/10.1021/acs.joc.4c01589 Kivonat

• Target-templated Construction of Functional Proteomimetics Using Photo-foldamer Libraries

  Edit Wéber , Péter Ábrányi-Balogh , Tamas A. Martinek , Bence Nagymihály , Dóra Karancsiné Menyhárd , Nikolett Péczka , Márton Gadanecz , Gitta Schlosser , Zoltán Orgován , Ferenc Bogár , Dávid Bajusz , Gábor Kecskeméti , Zoltán Szabó , Éva Bartus , Attila Tököli , Gábor K. Tóth , Tibor V. Szalai , Tamás Takács , Elvin de Araujo , László Buday , András Perczel , György M. Keserű

  Angew. Chem. Int. Ed. (2024) e202410435 I DOI: 10.1002/anie.202410435 Kivonat

• Opening Amyloid-Windows to the secondary structure of proteins: The amyloidogenecity increases tenfold inside beta-sheets

  Kristóf Takács , Bálint Varga , Viktor Farkas , András Perczel , Vince Grolmusz

  Computers in Biology and Medicine (2024) 179: 108863 Kivonat

• Solvent induced amyloid polymorphism and the uncovering of the elusive class 3 amyloid topology

  Zsolt Dürvanger , Fruzsina Bencs , Dóra K. Menyhárd , Dániel Horváth , András Perczel

  Communications Biology (2024) 7: 968 Kivonat

• Mapping protein binding sites by photoreactive fragment pharmacophores

  Péter Ábrányi-Balogh , Dávid Bajusz , Zoltán Orgován , Aaron B. Keeley , László Petri , Nikolett Péczka , Tibor Viktor Szalai , Gyula Pálfy , Márton Gadanecz , Emma K. Grant , Tímea Imre , Tamás Takács , Ivan Ranđelović , Marcell Baranyi , András Marton , Gitta Schlosser , Qirat F. Ashraf , Elvin D. de Araujo , Tamás Karancsi , László Buday , József Tóvári , András Perczel , Jacob T. Bush , György M. Keserű

  Communications Chemistry (2024) 7, 168 I DOI: https://doi.org/10.1038/s42004-024-01252-w Kivonat

• Contribution of Noncovalent Recognition and Reactivity to the Optimization of Covalent Inhibitors: A Case Study on KRasG12C

  Nikolett Péczka , Ivan Ranđelović , Zoltán Orgován , Noémi Csorba , Attila Egyed , László Petri , Péter Ábrányi-Balogh , Márton Gadanecz , András Perczel , József Tóvári , Gitta Schlosser , Tamás Takács , Levente M. Mihalovits , György G. Ferenczy , László Buday , György M. Keserű

  ACS Chem. Biol. (2024) 19, 8, 1743–1756 I DOI: https://doi.org/10.1021/acschembio.4c00217 Kivonat

• Dynamically encoded reactivity of Ras enzymes: opening new frontiers for drug discovery

  Gyula Pálfy , Dóra K. Menyhárd , András Perczel

  Cancer and Metastasis Reviews (2024) doi.org/10.1007/s10555-020-09917-3 Kivonat

• Neighbor effect on conformational spaces of alanine residue in azapeptides

  Ho-Jin Lee , Shi-Wei Liu , Máté Sulyok-Eiler , Veronika Harmat , Viktor Farkas , Zoltán Bánóczi , Mouna El Khabchi , Hua-Jun Shawn Fan , Kimihiko Hirao , Jong-Won Song

  Heliyon (2024) 10 (12), e33159 I DOI: https://doi.org/10.1016/j.heliyon.2024.e33159 Kivonat

• LoCoHD: a metric for comparing local environments of proteins

  Zsolt Fazekas , Dóra K. Menyhárd , András Perczel

  Nature Communications (2024) 15, 4029 I DOI: https://doi.org/10.1038/s41467-024-48225-0 Kivonat

• Revisiting Hafner’s Azapentalenes: The Chemistry of 1,3-Bis(dimethylamino)-2-azapentalene

  Enikő Meiszter , Tamás Gazdag , Péter J. Mayer , Attila Kunfi , Tamás Holczbauer , Máté Sulyok-Eiler , Gábor London

  J. Org. Chem. (2024) 89 (9), 5941-5951 | DOI: 10.1021/acs.joc.3c02564 Kivonat

• Unveiling the Oxazolidine Character of Pseudoproline Derivatives by Automated Flow Peptide Chemistry

  Szebasztián Szaniszló , Antal Csámpai , Dániel Horváth , Richárd Tomecz , Viktor Farkas , András Perczel

  International Journal of Molecular Sciences (2024) 25(8), 4150 Kivonat

• Influence of Aza-Glycine Substitution on the Internalization of Penetratin

  Karima Tarchoun , Dóra Soltész , Viktor Farkas , Ho-Jin Lee , Ildikó Szabó , Zoltán Bánóczi

  Pharmaceutics (2024) 16(4), 477 Kivonat

• Synthesis of small protein domains by automated flow chemistry

  Kristóf Ferentzi , Dóra Nagy-Fazekas , Viktor Farkas , András Perczel

  Reaction Chemistry & Engineering (2024) 9, 58-69 Kivonat

2023

• Amide isomerization pathways: Electronic and structural background of protonation- and deprotonation-mediated cis-trans interconversions

  Ádám A. Kelemen , András Perczel , Dániel Horváth , Imre Jákli

  J. Chem. Phys. (2023) 159 (15): 154301. | DOI: https://doi.org/10.1063/5.0165772 Kivonat

• Design and Characterization of a Multistage Peptide-Based Vaccine Platform to Target Mycobacterium tuberculosis Infection

  Chiara Bellini , Emil Vergara , Fruzsina Bencs , Kinga Fodor , Szilvia Bõsze , Denis Krivić , Bernadett Bacsa , Sára Eszter Surguta , József Tóvári , Rajko Reljic , Kata Horváti

  Bioconjugate Chemistry (2023) 34(10): 1738–1753 Kivonat

• Polymorphic amyloid nanostructures of hormone peptides involved in glucose homeostasis display reversible amyloid formation

  Dániel Horváth , Zsolt Dürvanger , Dóra K. Menyhárd , Máté Sulyok-Eiler , Fruzsina Bencs , Gergő Gyulai , Péter Horváth , Nóra Taricska , András Perczel

  Nature Communications (2023) 14, 4621 I https://doi.org/10.1038/s41467-023-40294-x Kivonat

• NMR-Chemical-Shift-Driven Protocol Reveals the Cofactor-Bound, Complete Structure of Dynamic Intermediates of the Catalytic Cycle of Oncogenic KRAS G12C Protein and the Significance of the Mg2+ Ion

  Márton Gadanecz , Zsolt Fazekas , Gyula Pálfy , Dóra Karancsiné Menyhárd , András Perczel

  Int. J. Mol. Sci. (2023) 24(15), 12101 I https://doi.org/10.3390/ijms241512101 Kivonat

• Inhibitor Design Strategy for Myostatin: Dynamics and Interaction Networks Define the Affinity and Release Mechanisms of the Inhibited Complexes

  Dóra Nagy-Fazekas , Zsolt Fazekas , Nóra Taricska , Pál Stráner , Dóra Karancsiné Menyhárd , András Perczel

  Molecules (2023) 28(15), 5655 | https://doi.org/10.3390/molecules28155655 Kivonat

• Crystal Nanoarchitectonics and Characterization of the Octahedral Iron(III)–Nitrate Complexes with Isomer Dimethylurea Ligands

  Kende Attila Béres , Zoltán Homonnay , Laura Bereczki , Zsolt Dürvanger , Vladimir M. Petruševski , Attila Farkas , László Kótai

  Crystals (2023) 13(7), 1019 I DOI: https://doi.org/10.3390/cryst13071019 I ISSN 2073-4352 Kivonat

• Acetyl group for proper protection of β-sugar-amino acids used in SPPS

  István Varga , Viktória Goldschmidt Gőz , István Pintér , Antal Csámpai , András Perczel

  Amino Acids (2023) | doi: 10.1007/s00726-023-03278-1 Kivonat

• Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry

  Szebasztián Szaniszló , Kristóf Ferentzi , András Perczel , Viktor Farkas

  Organic Process Research & Development (2023) 27(6): 1053-1060 Kivonat

• Effect of Substitution Degree and Homogeneity on Cyclodextrin-Ligand Complex Stability: Comparison of Fenbufen and Fenoprofen Using CD and NMR Spectroscopy

  Márta Kraszni , Ferenc Ágh , Dániel Horváth , Arash Mirzahosseini , Péter Horváth

  Int. J. Mol. Sci. (2023) 24, 7544. I DOI: https://doi.org/10.3390/ijms24087544 Kivonat

• A Novel Fusion Protein System for the Production of Nanobodies and the SARS-CoV-2 Spike RBD in a Bacterial System

  Dóra Nagy-Fazekas , Pál Stráner , Péter Ecsédi , Nóra Taricska , Adina Borbély , László Nyitray , András Perczel

  Bioengineering (2023) 10(3), 389 I DOI: 10.3390/bioengineering10030389 Kivonat

• Structures of calmodulin–melittin complexes show multiple binding modes lacking classical anchoring interactions

  Zsolt Dürvanger , Tünde Juhász , Károly Liliom , Veronika Harmat

  J. Biol. Chem. (2023) 299(4): 104596 I DOI: 10.1016/j.jbc.2023.104596 Kivonat

• Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency

  Zoltán Orgován , Nikolett Péczka , László Petri , Péter Ábrányi-Balogh , Ivan Ranđelović , Szilárd Tóth , Gergely Szakács , Kinga Nyíri , Beáta Vértessy , Gyula Pálfy , István Vida , András Perczel , József Tóvári , György M. Keserű

  European Journal of Medicinal Chemistry (2023) 250, 115212, ISSN 0223-5234 I DOI: 10.1016/j.ejmech.2023.115212. Kivonat

• Structural, Spectroscopic, and Thermal Decomposition Features of [Carbonatotetraamminecobalt(III)] Iodide—Insight into the Simultaneous Solid-Phase Quasi-Intramolecular Redox Reactions

  Kende Attila Béres , Fanni Szilágyi , Zoltán Homonnay , Zsolt Dürvanger , Laura Bereczki , László Trif , Vladimir M. Petruševski , Attila Farkas , Niloofar Bayat , László Kótai

  Inorganics (2023) 11(2):68. I DOI: https://doi.org/10.3390/inorganics11020068 Kivonat

2022

• A carbapenem antibiotic inhibiting a mammalian serine protease: structure of the acylaminoacyl peptidase–meropenem complex

  Anna J. Kiss-Szemán , Luca Takács , Zoltán Orgován , Pál Stráner , Imre Jákli , Gitta Schlosser , Simonas Masiulis , Veronika Harmat , Dóra K. Menyhárd , András Perczel

  Chemical Science (2022) 13, 14264 - 14276 I DOI: 10.1039/D2SC05520A Kivonat

• Comparative Study of the Solid-Liquid Interfacial Adsorption of Proteins in Their Native and Amyloid Forms

  Ágnes Ábrahám , Flavio Massignan , Gergő Gyulai , Miklós Katona , Nóra Taricska , Éva Kiss

  Int. J. Mol. Sci. (2022) 23(21), 13219 I DOI: 10.3390/ijms232113219 Kivonat

• D27-LIKE1 isomerase has a preference towards trans/cis and cis/cis conversions of carotenoids in Arabidopsis

  Zsolt Gulyás , Blanka Moncsek , Kamirán Áron Hamow , Pál Stráner , Zoltán Tolnai , Eszter Badics , Norbert Incze , Éva Darkó , Valéria Nagy , András Perczel , László Kovács , Vilmos Soós

  The Plant Journal (2022) DOI: 10.1111/tpj.16017 Kivonat

• Synthesis, structure, and Mössbauer spectroscopic studies on the heat‑induced solid‑phase redox reactions of hexakis(urea‑O)iron(III) peroxodisulfate

  Kende Attila Béres , Zoltán Homonnay , Berta Barta Holló , Maria Gracheva , Vladimir M. Petruševski , Attila Farkas , Zsolt Dürvanger , László Kótai

  Journal of Materials Research (2022) 38, 1102–1118 I DOI: 10.1557/s43578-022-00794-w Kivonat

• Succinct Amyloid and Nonamyloid Patterns in Hexapeptides

  László Keresztes , Evelin Szögi , Bálint Varga , Viktor Farkas , András Perczel , Vince Grolmusz

  ACS Omega (2022) DOI: 10.1021/acsomega.2c02513 Kivonat

• Thermally Induced Solid-Phase Quasi-Intramolecular Redox Reactions of [Hexakis(urea-O)iron(III)] Permanganate: An Easy Reaction Route to Prepare Potential (Fe,Mn)Ox Catalysts for CO2 Hydrogenation

  Kende Attila Béres , Zoltán Homonnay , Libor Kvitek , Zsolt Dürvanger , Martina Kubikova , Veronika Harmat , Fanni Szilágyi , Zsuzsanna Czégény , Péter Németh , Laura Bereczki , Vladimir M. Petruševski , Mátyás Pápai , Attila Farkas , László Kótai

  Inorg. Chem. (2022) 61(36), 14403–14418 I DOI: 10.1021/acs.inorgchem.2c02265 Kivonat

• Synthesis of the extracellular domain of GLP-1R by chemical and biotechnological approaches

  János Szolomajer , Pál Stráner , Zoltán Kele , Gábor K. Tóth , András Perczel

  RSC Advances (2022) 12: 24278-24287 | DOI: 10.1039/d2ra02784d Kivonat

• Omicron Binding Mode: Contact Analysis and Dynamics of the Omicron Receptor-Binding Domain in Complex with ACE2

  Zsolt Fazekas , Dóra K. Menyhárd , András Perczel

  Journal of Chemical Information and Modelling (2022) DOI: 10.1021/acs.jcim.2c00397 Kivonat

• The Importance of Mg2+-Free State in Nucleotide Exchange of Oncogenic K-Ras Mutants

  Gyula Pálfy , Dóra K. Menyhárd , Hanna Ákontz-Kiss , István Vida , Gyula Batta , Orsolya Tőke , András Perczel

  Chemistry - A European Journal (2022) e202201449 I DOI: doi.org/10.1002/chem.202201449 Kivonat

• Cryo-EM structure of acylpeptide hydrolase reveals substrate selection by multimerization and a multi-state serine-protease triad

  Anna J. Kiss-Szemán , Pál Stráner , Imre Jákli , Naoki Hosogi , Veronika Harmat , Dóra K. Menyhárd , András Perczel

  Chemical Science (2022) DOI: 10.1039/d2sc02276a Kivonat

• Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation

  Zoltán Attila Nagy , Dávid Héja , Dániel Bencze , Bence Kiss , Eszter Boros , Dávid Szakács , Krisztián Fodor , Matthias Wilmanns , Andrea Kocsis , József Dobó , Péter Gál , Veronika Harmat , Gábor Pál

  J. Biol. Chem. (2022) 298(6) 101985 I DOI: 10.1016/j.jbc.2022.101985 Kivonat

• Directed Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides

  Zsolt Dürvanger , Eszter Boros , Zoltán Attila Nagy , Rózsa Hegedüs , Márton Megyeri , József Dobó , Péter Gál , Gitta Schlosser , Annamária F. Ángyán , Zoltán Gáspári , András Perczel , Veronika Harmat , Gábor Mező , Dóra K. Menyhárd , Gábor Pál

  ACS Chem. Biol. (2022) 17(4), 969–986 I DOI: 10.1021/acschembio.2c00114 Kivonat

• The Structure-Derived Mechanism of Box H/ACA Pseudouridine Synthase Offers a Plausible Paradigm for Programmable RNA Editing

  Dóra Judit Kiss , Julianna Oláh , Gergely Tóth , Máté Varga , András Stirling , Dóra K. Menyhárd , György G. Ferenczy

  ACS Catal. (2022) 12 (5), 2756-2769 I DOI: 10.1021/acscatal.1c04870 Kivonat

2021

• Application of Sugar Amino Acids: Flow chemistry used for α/β-chimera synthesis

  Viktória Goldschmidt Gőz , Kim Hoang Yen Duong , Dániel Horváth , Kristóf Ferentzi , Viktor Farkas , András Perczel

  Eur. J. Org. Chem. (2021) 6071–6083. | In memory of Ferenc Fülöp Kivonat

• Solution Structure and Acid-Base Properties of Reduced α-Conotoxin MI

  Zoltán Faragó , Arash Mirzahosseini , Dániel Horváth , Tamás Pálla , Péter Horváth , András Perczel , Béla Noszál

  Chemistry & Biodiversity (2021) 18, e21004 I DOI: https://doi.org/10.1002/cbdv.202100464 Kivonat

• Dynamic disorder in the high-temperature polymorph of bis[diamminesilver(I)] sulfate-reasons and consequences of simultaneous ammonia release from two different polymorphs

  Laura Bereczki , Lara Alexandre Fogaça , Zsolt Dürvanger , Veronika Harmat , Katalin Kamarás , Gergely Németh , Berta Barta Holló , Vladimir M. Petruševski , Eszter Bódis , Attila Farkas , Imre Miklós Szilágyi , László Kótai

  Journal of Coordination Chemistry (2021) 74:13, 2144-2162 | DOI: 10.1080/00958972.2021.1953489 Kivonat

• The Budapest Amyloid Predictor and Its Applications

  László Keresztes , Evelin Szögi , Bálint Varga , Viktor Farkas , András Perczel , Vince Grolmusz

  Biomolecules (2021) 11(4), 500 | DOI: 10.3390/biom11040500 Kivonat

• Bacterial fermentation and isotope labelling optimized for amyloidogenic proteins

  István Vida , Zsolt Fazekas , Gergő Gyulai , Dóra Nagy-Fazekas , Gyula Pálfy , Pál Stráner , Éva Kiss , András Perczel

  Microbial Biotechnology (2021) 14, 1107–1119. | https://doi.org/10.1111/1751-7915.13778 Kivonat

• Synthesis of chimera oligopeptide including furanoid ß-sugar amino acid derivatives with free OHs: mild but successful removal of the 1,2-O-isopropylidene from the building block

  Duong Kim Hoang Yen , Viktória Goldschmidt Gőz , András Perczel , István Pintér

  Amino Acids (2021) 53: 281–294 | DOI: 10.1007/s00726-020-02923-3 Kivonat

• Cost Effective Flow Peptide Synthesis: Metamorphosis of HPLC

  Viktor Farkas , Kristóf Ferentzi , Kata Horváti , András Perczel

  Organic Process Research & Development (2021) 25(2): 182-191 Kivonat

2020

• Intrinsic structural disorder of proteins: from prediction to experimental identification

  Andrea Bodor

  Amino Acids, Peptides and Proteins (2020) https://doi.org/10.1039/9781788017008-00064 Kivonat

• Assessment of Tractable Cysteines for Covalent Targeting by Screening Covalent Fragments

  László Petri , Dr. Péter Ábrányi-Balogh , Dr. Imre Tímea , Dr. Gyula Pálfy , Prof. Dr. András Perczel , Dr. Damijan Knez , Dr. Martina Hrast , Dr. Martina Gobec , Dr. Izidor Sosič , Dr. Kinga Nyíri , Prof. Dr. Beáta G. Vértessy , Niklas Jänsch , Charlotte Desczyk , Prof. Dr. Franz‐Josef Meyer‐Almes , Iza Ogris , Dr. Simona Golič Grdadolnik , Luca Giacinto Iacovino , Prof. Dr. Claudia Binda , Prof. Dr. Stanislav Gobec , Prof. Dr. György M. Keserű

  ChemBioChem (2020) https://doi.org/10.1002/cbic.202000700 Kivonat

• Structural impact of GTP binding on downstream KRAS signaling

  Dóra K. Menyhárd , Gyula Pálfy , Zoltán Orgován , István Vida , György M. Keserű , András Perczel

  Chemical Science (2020) DOI: 10.1039/d0sc03441j Kivonat

• Power of Pure Shift HαCα Correlations: A Way to Characterize Biomolecules under Physiological Conditions

  Andrea Bodor , Jens D. Haller , Bouguechtouli Chafiaa , Theillet Francois-Xavier , László Nyitray , Luy Burkhard

  Analytical Chemistry (2020) https://doi.org/10.1021/acs.analchem.0c02182 Kivonat

• Interplay of Structural Disorder and Short Binding Elements in the Cellular Chaperone Function of Plant Dehydrin ERD14

  Nikoletta Murvai , Lajos Kalmár , Bianka Szalainé Ágoston , Beáta Szabó , Ágnes Tantos , György Csikós , András Micsonai , József Kardos , Didier Vertommen , Phuong N. Nguyen , Nevena Hristozova , András Láng , Dénes Kovács , László Buday , Kyou-Hoon Han , András Perczel , Péter Tompa

  Cells (2020) 9(8), 1856 | doi: 10.3390/cells9081856 Kivonat

• Pseudouridylation defect due to DKC1 and NOP10 mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis

  Balogh Eszter , Chandler Jennifer C. , Varga Máté , Tahoun Mona , Karancsiné Menyhárd Dóra , Schay Gusztáv , Goncalves Tomas , Hamar Renáta , Légrádi Regina , Szekeres Ákos

  https://www.pnas.org (2020) https://doi.org/10.1073/pnas.2002328117 Kivonat

• Gas Sensing by Bacterial H-NOX Proteins: An MD Study

  Rozza Ahmed M. , Dóra K. Menyhárd , Oláh Julianna

  Molecules (2020) https://doi.org/10.3390/molecules25122882 Kivonat

• Tumor‐Suppressor p53TAD1–60 Forms a Fuzzy Complex with Metastasis‐Associated S100A4: Structural Insights and Dynamics by an NMR/MD Approach

  Erika F. Dudás , Gyula Pálfy , Dóra K. Menyhárd , Fanni Sebák , Péter Ecsédi , László Nyitray , Andrea Bodor

  ChemBioChem (2020) 21 | doi.org/10.1002/cbic.202000348 Kivonat

• Podocin regulates the size of the glomerular pore

  Kétszeri Máté , Antal Violetta , Schay Gusztáv , Ungvári-Veres Anita , Pászty Katalin , Kellermayer Miklós , Karancsiné Menyhárd Dóra , Kálmán Tory

  Nephrology Dialysis Transplantation (2020) https://doi.org/10.1093/ndt/gfaa140.MO032 Kivonat

• Tissue-Specific Requirement for the GINS Complex During Zebrafish Development

  Varga Máté , Csályi Kitti , Bertyák István , Karancsiné Menyhárd Dóra , Poole Richard J. , Cerveny Kara L. , Kövesdi Dorottya , Barátki Balázs , Rouse Hannah , Vad Zsuzsa

  Frontiers in Cell and Developmental Biology (2020) https://doi.org/10.3389/fcell.2020.00373 Kivonat

• Structure Determination of the Transactivation Domain of p53 in Complex with S100A4 Using Annexin A2 as a Crystallization Chaperone

  Péter Ecsédi , Gergő Gógl , Henrietta Hóf , Bence Kiss , Veronika Harmat , László Nyitray

  Structure (2020) 28(8), 943-953.e4 | doi: 10.1016/j.str.2020.05.001 Kivonat

• Configuration‐Controlled Crystal and/or Gel Formation of Protected d‐Glucosamines Supported by Promiscuous Interaction Surfaces and a Conformationally Heterogeneous Solution State

  Anita Kapros , Attila Balázs , Veronika Harmat , Adrienn Háló , Lívia Budai , István Pintér , Dóra K. Menyhárd , András Perczel

  Chemistry—A European Journal (2020) 26 | doi.org/10.1002/chem.202000882 Kivonat

• 1H, 15N backbone assignment and comparative analysis of the wild type and G12C, G12D, G12V mutants of K‐Ras bound to GDP at physiological pH

  Gyula Pálfy , István Vida , András Perczel

  Biomolecular NMR Assignments (2020) 14, 1-7 | doi.org/10.1007/s12104-019-09909-7 Kivonat

• Novel Polycondensed Partly Saturated β-Carbolines Including Ferrocene Derivatives: Synthesis, DFT-Supported Structural Analysis, Mechanism of Some Diastereoselective Transformations and a Preliminary Study of their In Vitro Antiproliferative Effects

  Kinga Judit Fodor , Dániel Hutai , Tamás Jernei , Angéla Takács , Zsófia Szász , Máté Sulyok-Eiler , Veronika Harmat , Rita Oláh Szabó , Gitta Schlosser , Ferenc Hudecz , László Kőhidai , Antal Csámpai

  Molecules (2020) 25(7), 1599 | doi: 10.3390/molecules25071599 Kivonat

• Anionic food color tartrazine enhances antibacterial efficacy of histatin-derived peptide DHVAR4 by fine-tuning its membrane activity

  Maria Ricci , Kata Horváti , Tünde Juhász , Imola Szigyártó , György Török , Fanni Sebák , Andrea Bodor , László Homolya , Judit Henczkó , Bernadett Pályi , Tamás Mlinkó , Judith Mihály , Bilal Nizami , Zihuayuan Yang , Fengming Lin , Xiaolin Lu , Loránd Románszki , Attila Bóta , Zoltán Varga , Szilvia Bõsze , Ferenc Zsila , Tamás Beke-Somfai

  Quarterly Reviews of Biophysics (2020) 53(5), 1-11 | DOI: 10.1017/S0033583520000013 Kivonat

• Compactness of Protein Folds Alters Disulfide‐Bond Reducibility by Three Orders of Magnitude: A Comprehensive Kinetic Case Study on the Reduction of Differently Sized Tryptophan Cage Model Proteins

  Dániel Horváth , Nóra Taricska , Ernő Keszei , Pál Stráner , Viktor Farkas , Gábor K. Tóth , András Perczel

  ChemBioChem (2020) 21(5), 681-695 | doi.org/10.1002/cbic.201900470 Kivonat

• The route from the folded to the amyloid state: exploring the potential energy surface of a drug-like miniprotein

  Nóra Taricska , Dániel Horváth , Dóra K. Menyhárd , Hanna Ákontz-Kiss , Masahiro Noji , Masatomo So , Yuji Goto , Toshimichi Fujiwara , András Perczel

  Chemistry A European Journal (2020) 26(9), 1968-1978 | doi.org/10.1002/chem.201903826 Kivonat

• Podocin Regulates the Nephrin-Nephrin Distance in the Glomerular Pore

  Schay Gusztáv , Antal Violetta , Kétszeri Máté , Csokay Katalin , Kellermayer Miklós , Dóra K. Menyhárd , Kálmán Tory

  Biophysical Journal (2020) DOI:https://doi.org/10.1016/j.bpj.2019.11.2889 Kivonat

• Peptide-bicelle interaction: Following variations in size and morphology by a combined NMR-SAXS approach

  E. F. Dudás , A. Wacha , A. Bóta , A. Bodor

  Biochimica et Biophysica Acta (BBA) - Biomembranes (2020) doi.org/10.1016/j.bbamem.2019.183095 Kivonat

• Off-pathway 3D-structure provides protection against spontaneous Asn/Asp isomerization: shielding proteins Achilles heel

  András Láng , Imre Jákli , Kata Nóra Enyedi , Gábor Mező , Dóra K. Menyhárd , András Perczel

  Quarterly Reviews of Biophysics (2020) 53 | doi:10.1017/S003358351900009X Kivonat

• Effect of podocin variants on the podocin-nephrin and nephrin-nephrin interaction

  Antal Violetta , Kétszeri Máté , Gusztáv Schay , Ungvári-Veres Anita , Csokay Katalin , Dóra K. Menyhárd , Kálmán Tory , Kellermayer Miklós

  Orvosképzés (2020)

2019

• Allélspecifikus inhibitorok nyomában: a RASopátia konzorcium célpontjában a KRAS fehérje onkogén mutációi

  Kinga Nyíri , Gergely Koppány , Gyula Pálfy , István Vida , Szilárd Tóth , Zoltán Orgován , Ivan Ranđelović , Marcell Baranyi , Eszter Molnár , György M. Keserű , József Tóvári , András Perczel , Beáta G. Vértessy , József Tímár

  Magyar Onkológia (2019) 63(4), 310-323 Kivonat

• Structural Diversity in Calmodulin - Peptide Interactions

  Zsolt Dürvanger , Veronika Harmat

  Current Protein & Peptide Science (2019) 1102 - 1111 doi.org/10.2174/1389203720666190925101937 Kivonat

• Achieving Functionality Through Modular Build-up: Structure and Size Selection of Serine Oligopeptidases

  Anna J. Kiss-Szemán , Veronika Harmat , Dóra K. Menyhárd

  Current Protein & Peptide Science (2019) 1089 - 1101 DOI:10.2174/1389203720666190925103339 Kivonat

• Unwanted hydrolysis or α/β-peptide bond formation: how long should the rate-limiting coupling step take?

  Viktória Goldschmidt Gőz , Adrienn Nagy , Viktor Farkas , Ernő Keszei , András Perczel

  RSC Advances (2019) 9(53): 30720–30728 | DOI: 10.1039/c9ra06124j Kivonat

• Assignment of vibrational circular dichroism cross-referenced electronic circular dichroism spectra of flexible foldamer building blocks: towards assigning foldamers’ pure chiroptical properties

  Viktor Farkas , Adrienn Nagy , Dóra K. Menyhárd , András Perczel

  Chemistry A European Journal (2019) 25(65): 14890-14900 | doi.org/10.1002/chem.201903023 Kivonat

• A Convenient Synthetic Method to Improve Immunogenicity of Mycobacterium tuberculosis Related T-Cell Epitope Peptides

  Kata Horváti , Bernadett Pályi , Judit Henczkó , Gyula Balka , Eleonóra Szabó , Viktor Farkas , Beáta Biri-Kovács , Bálint Szeder , Kinga Fodor

  Vaccines (2019) 7(3), 101, doi:10.3390/vaccines7030101 Kivonat

• Radiation-damage investigation of a DNA 16-mer

  Valéria Bugris , Veronika Harmat , Györgyi Ferenc , Sándor Brockhauser , Ian Carmichael , Elspeth F. Garman

  Journal of Synchrotron Radiation (2019) 998-1009 doi.org/10.1107/S160057751900763X Kivonat

• Real-time pure shift measurements for uniformly isotope-labeled molecules using X-selective BIRD homonuclear decoupling

  Jens D. Haller , Andrea Bodor , Burkhard Luy

  Journal of Magnetic Resonance (2019) 64-71 doi.org/10.1016/j.jmr.2019.03.011 Kivonat

• 1,3-Dipolar Cycloaddition of Isatin-Derived Azomethine Ylides with 2H‐Azirines: Stereoselective Synthesis of 1,3- Diazaspiro[bicyclo[3.1.0]hexane]oxindoles

  Anikó Angyal , András Demjén , Veronika Harmat , János Wölfling , László G. Puskás , Iván Kanizsai

  The Journal of Organic Chemistry (2019) 4273-4281 DOI: 10.1021/acs.joc.9b00242 Kivonat

• Hydration shell differentiates folded and disordered states of a trp-cage miniprotein, allowing characterization of structural heterogeneity by wide-line NMR measurements

  Nóra Taricska , Mónika Bokor , Dóra K. Menyhárd , Kálmán Tompa , András Perczel

  Scientific Reports (2019) 9:2947 doi.org/10.1038/s41598-019-39121-5 Kivonat

• DUckCov: a Dynamic Undocking-Based Virtual Screening Protocol for Covalent Binders

  Moira Rachman , Andrea Scarpino , Dávid Bajusz , Gyula Pálfy , István Vida , András Perczel , Xavier Barril , György M. Keserű

  ChemMedChem (2019) 14, 1 – 12 DOI: 10.1002/cmdc.201900078 Kivonat

• Quantitative, Diffusion NMR Based Analytical Tool To Distinguish Folded, Disordered, and Denatured Biomolecules

  Erika F. Dudás , Andrea Bodor

  American Chemical Society (2019) 4929-4933 DOI: 10.1021/acs.analchem.8b05617 Kivonat

• Directed Evolution of Canonical Loops and Their Swapping between Unrelated Serine Proteinase Inhibitors Disprove the Interscaffolding Additivity Model

  Eszter Boros , Fanni Sebák , Dávid Héja , Dávid Szakács , Katalin Zboray , Gitta Schlosser , András Micsonai , József Kardos , Andrea Bodor , Gábor Pál

  J. Mol. Biol. (2019) 431, 557–575 | doi.org/10.1016/j.jmb.2018.12.003 Kivonat

• α/β‐Chimera peptide synthesis with cyclic β‐sugar amino acids: the efficient coupling protocol

  Adrienn Nagy , Viktória Goldschmidt Gőz , István Pintér , Viktor Farkas , András Perczel

  Amino Acids (2019) 51(4), 669-678 Kivonat

• Protein Aggregation in a Nutshell: The Splendid Molecular Architecture of the Dreaded Amyloid Fibrils

  Dániel Horváth , Dóra K. Menyhárd , András Perczel

  Current Protein & Peptide Science (2019) 20(11), 1077-1088 | doi: 10.2174/1389203720666190925102832. Kivonat

2018

• Quantum chemical calculations support pseudouridine synthase reaction through a glycal intermediate and provide details of the mechanism

  Dóra J. Kiss , Julianna Oláh , Gergely Tóth , Dóra K. Menyhárd , György G Ferenczy

  Springer Berlin Heidelberg (2018) 137-162 | doi.org/10.1007/s00214-018-2361-6 Kivonat

• Crystal and solution structures of calcium complexes relevant to problematic waste disposal: calcium gluconate and calcium isosaccharinate

  V. Bugris , Cs. Dudás , B. Kutus , V. Harmat , K. Csankó , S. Brockhauser , I. Pálinkó , Peter Turner , P. Sipos

  Acta Crystallographica Section B (2018) 598-609 | doi.org/10.1107/S2052520618013720 Kivonat

• The mutation-dependent pathogenicity of NPHS2 p.R229Q: A guide for clinical assessment

  Ágnes Mikó , Dóra K. Menyhárd , Ambrus Kaposi , Corinne Antignac , Kálmán Tory

  Wiley Online Library (2018) 1854-1860 | DOI: 10.1002/humu.23660 Kivonat

• In Situ Terminal Functionalization of Polystyrene Obtained by Quasiliving ATRP and Subsequent Derivatizations

  György Kasza , Györgyi Szarka , Andrea Bodor , Gergely Kali , Béla Iván

  American Chemical Society (2018) 1285, 281-295 | DOI: 10.1021/bk-2018-1285.ch015 Kivonat

• Multiple S100 protein isoforms and C-terminal phosphorylation contribute to the paralog-selective regulation of nonmuscle myosin 2 filaments

  Péter Ecsédi , Neil Billington , Gyula Pálfy , László Nyitray , Bence Kiss , Éva Bulyáki , Andrea Bodor , James R. Sellers

  The Journal of Biological Chemistry (2018) 293(38) 14850 –14867. | DOI10.1074/jbc.RA118.004277 Kivonat

• C-terminal oligomerization of podocin mediates interallelic interactions

  Pál Stráner , Eszter Balogh , Gusztáv Schay , Christelle Arrondel , Ágnes Mikó , Gerda L'Auné , Alexandre Benmerah , András Perczel , Dóra K. Menyhárd , Corinne Antignac , Géraldine Mollet , Kálmán Tory

  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2018) S0925-4439(18)30132-30137 | DOI: 10.1016/j.bbadis.2018.04.008 | PMID: 29660491 Kivonat

• Synthesis and in vitro biochemical evaluation of oxime bond- linked daunorubicin–GnRH-III conjugates developed for targeted drug delivery

  Viktor Farkas , Gábor Mező , László Buday , Beáta Biri-Kovács , Bálint Szeder , Sabine Schuster , Zsuzsanna Szabó , Gábor Halmos

  Beilstein Journal of Organic Chemistry (2018) 14, 756–771. doi:10.3762/bjoc.14.64 Kivonat

• Synthesis, spectral- and theoretical study, x-ray analysis, and antiproliferative activity of 4,5-dihydrobenzoferroceno[1,2-d][1,2,3]selenadiazole and its benzo-fused analogue

  Tibor Pasinszki , Dániel Dzsotján , Győző György Lajgut , Veronika Harmat , Antal Csámpai , Andrea Bor , István Zupkó

  Journal of Organometallic Chemistry (2018) 863:70-76. | DOI: 10.1016/j.jorganchem.2018.03.031 Kivonat

• Synthesis and in vitro biochemical evaluation of oxime bond-linked daunorubicin–GnRH-III conjugates developed for targeted drug delivery

  Sabine Schuster , Beáta Biri-Kovács , Bálint Szeder , Viktor Farkas , László Buday , Zsuzsanna Szabó , Gábor Halmos , Gábor Mező

  Beilstein J. Org. Chem. (2018) Beilstein J. Org. Chem. 14:756–771 | DOI:10.3762/bjoc.14.64 Kivonat

• New Antimicrobial Potential and Structural Properties of PAFB: A Cationic, Cysteine-Rich Protein from Penicillium chrysogenum Q176

  Anna Huber , Dorottya Hajdu , Doris Bratschun-Khan , Zoltán Gáspári , Mihayl Varbanov , Stéphanie Philippot , Ádám Fizil , András Czajlik , Zoltán Kele , Christoph Sonderegger , László Galgóczy , Andrea Bodor , Florentine Marx , Gyula Batta

  Scientific Reports (2018) 8:1751. PMID: 29379111 | DOI:10.1038/s41598-018-20002-2 Kivonat

• Approaches to Pyranuronic beta-Sugar Amino Acid Building Blocks of Peptidosaccharide Foldamers

  Viktória Goldschmidt Gőz , István Pintér , Veronika Harmat , András Perczel

  Eur. J. Org. Chem. (2018) 355-361. DOI: 10.1002/ejoc.201701612 Kivonat

• Dynamic control of RSK complexes by phosphoswitch-based regulation

  Gergő Gógl , Beáta Biri-Kovács , Ádám L Póti , Henrietta Vadászi , Bálint Szeder , Andrea Bodor , Gitta Schlosser , András Ács , Lilla Turiák , László Buday , Anita Alexa , László Nyitray , Attila Reményi

  FEBS J (2018) 285:46-71. PMID: 29083550 | DOI: 10.1111/febs.14311 Kivonat

2017

• First principles calculation of the reaction rates for ligand binding to myoglobin: the cases of NO and CO

  Anikó Lábas , Dóra K. Menyhárd , Jeremy N. Harvey , Julianna Oláh

  Wiley Online Library (2017) 5350-5358 | doi.org/10.1002/chem.201704867 Kivonat

• The impact of water on the ambivalent behavior and paradoxical phenomenon of the amyloid-β fibril protein

  Tamás Vajda , András Perczel

  Biomol. Concepts (2017) 8(5-6):213-220. PMIID: 29211680 | DOI: 10.1515/bmc-2017-0027 Kivonat

• Biochemical and pharmacological characterization of three opioid- nociceptin hybrid peptide ligands reveals substantially differing modes of their actions

  Anna I. Erdei , Adina Borbély , Anna Magyar , Nóra Taricska , András Perczel , Ottó Zsíros , Győző Garab , Edina Szűcs , Ferenc Ötvös , Ferenc Zádor , Mihály Balogh , Mahmoud Al-Khrasani , Sándor Benyhe

  Elsevier (2017) 205-216 | doi.org/10.1016/j.peptides.2017.10.005 Kivonat

• The Piwi-piRNA pathway: road to immortality

  Ádám Sturm , András Perczel , Zoltán Ivics , Tibor Vellai

  Aging Cell (2017) 16:906-911. PMID: 28653810 | DOI: 10.1111/acel.12630 Kivonat

• Ezrin interacts with S100A4 via both its N- and C-terminal domains

  Beáta Biri-Kovács , Bence Kiss , Henrietta Vadászi , Gergő Gógl , Gyula Pálfy , György Török , László Homolya , Andrea Bodor , László Nyitray

  PLoS One (2017) 12(5):e0177489 | doi: 10.1371/journal.pone.0177489 | PMID: 28493957 Kivonat

• Four Faces of the Interaction between Ions and Aromatic Rings

  Dóra Papp , Petra Rovó , Imre Jákli , Attila G. Császár , András Perczel

  Journal of Computational Chemistry (2017) 38, 1762-1773 | doi.org/10.1002/jcc.24816 Kivonat

• Strong influence of intramolecular Si⋯O proximity on reactivity: Systematic molecular structure, solvolysis, and mechanistic study of cyclic N-trimethylsilyl carboxamide derivatives

  Roland Szalay , Veronika Harmat , János Eőri , Gábor Pongor

  Tetrahedron Letters (2017) 58(23):2186-2192. | DOI: 10.1016/j.tetlet.2017.04.057 Kivonat

• How weak an acid can be? Variations of H-bond and/or van der Waals Interaction of Weak Acids

  Szebasztián Szaniszló , Imre G. Csizmadia , András Perczel

  Struct. Chem. (2017) 28(2):371-378. | DOI: 10.1007/s11224-016-0888-5 Kivonat

• Predictable conformational diversity in foldamers of sugar amino acids

  Dóra K. Menyhárd , Ilona Hudáky , Imre Jákli , György Juhász , András Perczel

  J. Chem. Inf. Model. (2017) 57(4):757–768. DOI: 10.1021/acs.jcim.6b00488 Kivonat

• C‐3 epimers of sugar amino acids as foldameric building blocks: improved synthesis, useful derivatives, coupling strategies

  Adrienn Nagy , Barbara Csordás , Virág Zsoldos-Mády , István Pintér , Viktor Farkas , András Perczel

  Amino Acids (2017) 49(2):223–240. | doi: 10.1007/s00726-016-2346-5 | PMID: 27803987 Kivonat

• Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins

  Tibor Szénási , Judit Oláh , Adél Szabó , Sándor Szunyogh , András Láng , András Perczel , Attila Lehotzky , Vladimir N. Uversky , Judit Ovádi

  Biochim Biophys Acta - Molecular Basis of Disease (2017) 1863(1):310-323. DOI: 10.1016/j.bbadis.2016.09.017. | PMID: 27671864 Kivonat

2016

• The Eighth Central European Conference “Chemistry towards Biology”: Snapshot

  András Perczel , Ricardo D. Enriz , Atanas G. Atanasov , Vladimír Sklenář , Jiří Nováček , Veronika Papoušková , Pavel Kadeřávek , Lukáš Žídek , Henryk Kozłowski , Joanna Wątły , Aleksandra Hecel , Paulina Kołkowska , Jaroslav Koča , Radka Svobodová-Vařeková , Lukáš Pravda , David Sehnal , Vladimír Horský , Stanislav Geidl , Pavel Matějka , Adéla Jeništová , Marcela Dendisová , Alžběta Kokaislová , Volkmar Weissig , Mark Olsen , Aidan Coffey , Jude Ajuebor , Ruth Keary , Marta Sanz-Gaitero , Mark J. van Raaij , Olivia McAuliffe , Birgit Waltenberger , Andrei Mocan , Karel Šmejkal , Elke H. Heiss , Marc Diederich , Robert Musioł , Janez Košmrlj , Jarosław Polański , Josef Jampílek

  Molecules (2016) 21(10):1381 DOI:10.3390/molecules21101381 Kivonat

• Origin of problems related to Staudinger reduction in carbopeptoid syntheses

  Barbara Csordás , Adrienn Nagy , Veronika Harmat , Virág Zsoldos-Mády , Ibolya Leveles , István Pintér , Viktor Farkas , András Perczel

  Amino Acids (2016) 48(11):2619-2633 DOI: 10.1007/s00726-016-2289-x | PMID: 27438266 Kivonat

• Multi-level changes in protein dynamics upon complex formation of the calcium-loaded S100A4 with a non-muscle myosin IIA tail fragment

  Gyula Pálfy , Bence Kiss , László Nyitray , Andrea Bodor

  ChemBioChem (2016) 17(19):1829-1838 DOI: 10.1002/cbic.201600280 | PMID: 27418229 Kivonat

• Aromatic cluster sensor of protein folding: near-UV ECD bands assigned to fold compactness

  Viktor Farkas , Imre Jákli , Gábor K. Tóth , András Perczel

  Chemistry A Eur. J. (2016) 22(39):13871–13883. DOI: 10.1002/chem.201602455 | PMID: 27504963 Kivonat

• Hydrogen-Bonding Network Anchors the Cyclic Form of Sugar Arylhydrazones

  Viktória Goldschmidt Gőz , István Pintér , Antal Csámpai , Imre Jákli , Virág Zsoldos-Mády , András Perczel

  Eur. J. Org. Chem. (2016) 20:3419-3426. DOI: 10.1002/ejoc.201600462 Kivonat

• The clear and dark sides of water: influence on the coiled coil folding domain

  Tamás Vajda , András Perczel

  Biomol.Concepts (2016) 7(3):189-195. DOI:10.1515/bmc-2016-0005 | PMID: 27180359 Kivonat

• Bacterial expression and/or solid phase peptide synthesis of 20-40 amino acid long polypeptides and miniproteins, the case study of Class B GPCR ligands

  Pál Stráner , Nóra Taricska , Mária Szabó , Gábor K. Tóth , András Perczel

  Curr. Prot. Pept. Sci. (2016) 17(2):147-155. DOI: 10.2174/1389203716666151102105215 | PMID: 26521952 Kivonat

• Small Peptides Derived from Penetratin as Antibacterial Agents

  Oscar Parravicini , Csaba Somlai , Sebastián A. Andujar , Adriana D. Garro , Beatriz Lima , Alejandro Tapia , Gabriela Feresin , András Perczel , Gábor Tóth , Javier López Cascales , Ana M. Rodríguez , Ricardo D. Enriz

  Arch.Pharm.Chem.Life.Sci. (2016) 349:242-251. DOI: 10.1002/ardp.201500419 Kivonat

• Structural basis of Ribosomal S6 Kinase 1 (RSK1) inhibition by S100B Protein: modulation of the Extracellular Signal-regulated Kinase (ERK) signaling cascade in a calcium-dependent way

  Gergő Gógl , Anita Alexa , Bence Kiss , Gergely Katona , Mihály Kovács , Andrea Bodor , Attila Reményi , László Nyitray

  J. Biol. Chem. (2016) 291(1):11-27. DOI: 10.1074/jbc.M115.684928 | PMID: 26527685 Kivonat

2015

• An engineered scorpion toxin analogue with improved Kv1.3 selectivity displays reduced conformational flexibility

  Ádám Bartók , Krisztina Fehér , Andrea Bodor , Kinga Rákosi , Gábor K. Tóth , Katalin E. Kövér , György Panyi , Zoltán Varga

  Scientific Reports (2015) 5:18397. DOI: 10.1038/srep18397 | PMID: 26689143 Kivonat

• Chiral recognition studies of α‑(nona fluoro-tert-butoxy)carboxylic acids by NMR spectroscopy

  Anikó Nemes , Tamás Csóka , Szabolcs Béni , Viktor Farkas , József Rábai , Dénes Szabó

  J. Org. Chem. (2015) 80(12):6267–6274 | DOI: 10.1021/acs.joc.5b00706 | PMID: 26024423 Kivonat

• Structural assembly of the signaling competent ERK2–RSK1 heterodimeric protein kinase complex

  Anita Alexa , Gergő Gógl , Gábor Glatz , Ágnes Garai , András Zeke , János Varga , Erika Dudás , Norbert Jeszenői , Andrea Bodor , Csaba Hetényi , Attila Reményi

  Proc. Natl. Acad. Sci. USA (2015) 112(9):2711-2716. | DOI: 10.1073/pnas.1417571112 | PMID: 25730857 Kivonat

• Membrane interactions in small fast-tumbling bicelles as studied by 31P NMR

  Andrea Bodor , Katalin E. Kövér , Lena Mäler

  BBA Biomembranes (2015) 1848(3):760-766. | DOI: 10.1016/j.bbamem.2014.12.001 | PMID: 25497765 Kivonat

• Catalytically distinct states captured in a crystal lattice: the substrate-bound and scavenger states of acylaminoacyl peptidase and their implications for functionality

  Dóra K. Menyhárd , Zoltán Orgován , Zoltán Szeltner , Ilona Szamosi , Veronika Harmat

  Acta Crystallogr D Biol Crystallogr. (2015) 71(Pt 3):461-472. | DOI: 10.1107/S1399004714026819 | PMID: 25760596 Kivonat

• Development of Cyclic NGR Peptides with Thioether Linkage: Structure and Dynamics Determining Deamidation and Bioactivity

  Kata N. Enyedi , András Czajlik , Krisztina Knapp , András Láng , Zsuzsa Majer , Eszter Lajkó , László Kőhidai , András Perczel , Gábor Mező

  J. Med. Chem. (2015) 58(4):1806-1817. | DOI: 10.1021/jm501630j | PMID: 25646854 Kivonat

• Phosphorylation as Conformational Switch from the Native to Amyloid State: Trp-Cage as a Protein Aggregation Model

  József Kardos , Bence Kiss , András Micsonai , Petra Rovó , Dóra K. Menyhárd , János Kovács , Gábor K. Tóth , András Perczel

  J. Phys. Chem. B (2015) 119(7):2946–2955. | DOI: 10.1021/jp5124234 | PMID: 25625571 Kivonat

2014

• DYNLL2 Dynein Light Chain Binds to an Extended Linear Motif of Myosin 5a Tail That Has Structural Plasticity

  Andrea Bodor , László Radnai , Csaba Hetényi , Péter Rapali , András Láng , Katalin E. Kövér , András Perczel , Weixiao Y. Wahlgren , Gergely Katona , László Nyitray

  Biochemistry (2014) 53(45):7107-7122. | DOI: 10.1021/bi500574z | PMID: 25312846 Kivonat

• Dynamics of small, folded proteins

  Petra Rovó , Dóra K. Menyhárd , Gábor Náray-Szabó , András Perczel

  Protein Modelling (2014) 223-248 |doi.org/10.1007/978-3-319-09976-7_10 Kivonat

• Role of water in protein folding, oligomerization, amyloidosis and miniprotein

  Tamás Vajda , András Perczel

  J. Pept. Sci. (2014) 20(10):747-759. | DOI: 10.1002/psc.2671. | PMID: 25098401 Kivonat

• Conservative Evolution, Sustainability, and Culture

  Gábor Náray-Szabó

  Comparative Literature and Culture (2014) 16(1) |doi.org/10.7771/1481-4374.2316> Kivonat

• Protein structure and dynamics

  Gábor Náray-Szabó , András Perczel

  Int. J. Terraspace Sci. Eng. (2014) 6:7-16 Kivonat

• Strictly localised molecular orbitals in QM/MM methods

  György G Ferenczy , Gábor Náray-Szabó

  Protein Modelling (2014) 71-89 |doi.org/10.1007/978-3-319-09976-7_4 Kivonat

• Probing of primed and unprimed sites of calpains: Design, synthesis and evaluation of epoxysuccinyl-peptide derivatives as selective inhibitors

  Levente E Dókus , Dóra K. Menyhárd , Ágnes Tantos , Ferenc Hudecz , Zoltán Bánóczi

  European Journal of Medicinal Chemistry (2014) 82:274-280. | DOI: 10.1016/j.ejmech.2014.05.058 | PMID: 24915003 Kivonat

• Rational Design of α-Helix-Stabilized Exendin-4 Analogues

  Petra Rovó , Viktor Farkas , Pál Stráner , Mária Szabó , Ágnes Jermendy , Orsolya Hegyi , Gábor K. Tóth , András Perczel

  Biochemistry (2014) 53(22):3540-3552. | DOI: 10.1021/bi500033c | PMID: 24828921 Kivonat

• The C-terminal random coil region tunes the Ca²⁺-binding affinity of S100A4 through conformational activation

  Annette Duelli , Bence Kiss , Ida Lundholm , Andrea Bodor , Maxim V. Petoukhov , Dmitri I. Svergun , László Nyitray , Gergely Katona

  PLoS One (2014) 9(5):e97654 | DOI: 10.1371/journal.pone.0097654 | PMID: 24830809 Kivonat

• On the Mechanism of Bifunctional Squaramide-Catalyzed Organocatalytic Michael Addition: A Protonated Catalyst as an Oxyanion Hole

  Bianka Kótai , György Kardos , Andrea Hamza , Viktor Farkas , Imre Pápai , Tibor Soós

  Chem. Eur. J. (2014) 20(19):5631-5639. | DOI: 10.1002/chem.201304553 | PMID: 24677388 Kivonat

• Önszerveződés és hajlékonyság: szubsztrát szelekciós stratégiák oligopeptidázokban

  Harmat Veronika

  MAGYAR KÉMIAI FOLYÓIRAT - KÉMIAI KÖZLEMÉNYEK (2014) 120(4):155-158

• Impairment of a model peptide by oxidative stress: Thermodynamic stabilities of asparagine diamide Cα-radical foldamers

  Klára Z. Gerlei , Lilla Élő , Béla Fiser , Michael C. Owen , Imre Jákli , Svend J. Knak Jensen , Imre G. Csizmadia , András Perczel , Béla Viskolcz

  Chem. Phys. Lett. (2014) 593:104–108. | DOI: 10.1016/j.cplett.2013.12.037 Kivonat

• A theoretical study of the stability of disulfide bridges in various β-sheet structures of protein segment models

  Natalie J. Galant , Heeyeon Cheryl Song , Imre Jákli , Béla Viskolcz , Imre G. Csizmadia , Svend J. Knak Jensen , András Perczel

  Chem. Phys. Lett. (2014) 593:48–54. | DOI: 10.1016/j.cplett.2013.12.065 Kivonat

• Mutation-dependent recessive inheritance of NPHS2-associated steroid-resistant nephrotic syndrome

  Kálmán Tory , Dóra K. Menyhárd , Stéphanie Woerner , Fabien Nevo , Olivier Gribouval , Andrea Kerti , Pál Stráner , Christelle Arrondel , Evelyne Huynh Cong , Tivadar Tulassay , Géraldine Mollet , András Perczel , Corinne Antignac

  Nat. Genet. (2014) 46:299–304 | DOI: 10.1038/ng.2898 | PMID: 24509478 Kivonat

2013

• Structure and enzymatic mechanism of a moonlighting dUTPase

  Ibolya Leveles , Veronika Németh , Judit E. Szabó , Veronika Harmat , Kinga Nyíri , Ábris Ádám Bendes , Veronika Papp-Kádár , Imre Zagyva , Gergely Róna , Olivér Ozohanics , Károly Vékey , Judit Tóth , Beáta G. Vértessy

  Acta Crystallogr D Biol Crystallogr. (2013) D69:2298-2308. | DOI: 10.1107/S0907444913021136 | PMID: 24311572 Kivonat

• Atropisomerism of the Asn α Radicals Revealed by Ramachandran Surface Topology.

  Klára Z. Gerlei , Imre Jákli , Milán Szőri , Svend J. Knak Jensen , Béla Viskolcz , Imre G. Csizmadia , András Perczel

  J. Phys. Chem. B (2013) 117(41):12402-12409. | DOI: 10.1021/jp4070906 | PMID: 24015919 Kivonat

• Multiple fuzzy interactions in the moonlighting function of thymosin-β4

  Ágnes Tantos , Beáta Szabó , András Láng , Zoltán Varga , Maksym Tsylonok , Mónika Bokor , Tamás Verebélyi , Pawel Kamasa , Kálmán Tompa , András Perczel , László Buday , Si Hyung Lee , Yejin Choo , Kyou-Hoon Han , Péter Tompa

  Intrinsically Disordered Proteins (2013) Kivonat

• Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, ³¹P-NMR spectroscopy and reaction path modelling

  Orsolya Barabás , Vince Grolmusz , Zoltán Szabadka , Imre Zagyva , Zoltán Kele , Edina Rosta , András Perczel , Andrea Bodor , Veronika Németh , Matthias Wilmanns

  Nucleic Acids Res. (2013) DOI: 10.1093/nar/gkt756 | PMID: 23982515 Kivonat

• Penetratin and derivatives acting as antibacterial agents

  Adriana D. Garro , Ana M. Rodríguez , Javier López Cascales , Botond Penke , Csaba Somlai , András Perczel , Gabriela Feresin , Alejandro Tapia , Beatriz Lima , José A. Bombasaro , Mónica S. Olivella , Ricardo D. Enriz

  Chem. Biol. Drug. Des. (2013) 82(2):167-177. | DOI: 10.1111/cbdd.12143 | PMID: 23581817 Kivonat

• Quantum Mechanical Modeling: A Tool for the Understanding of Enzyme Reactions

  Gábor Náray-Szabó , Julianna Oláh , Balázs Krámos

  Biomolecules (2013) 3:662-702. | DOI: 10.3390/biom3030662 Kivonat

• Foldamers of β-peptides: conformational preference of peptides formed by rigid building blocks. The first MI-IR spectra of a triamide nanosystem.

  Gábor Pohl , Esther Gorrea , Vicenç Branchadell , Rosa M. Ortuño , András Perczel , György Tarczay

  Amino Acids (2013) 45(4):957-973. | DOI: 10.1007/s00726-013-1552-7 | PMID: 23860847 Kivonat

• A self-compartmentalizing hexamer serine protease from Pyrococcus horikoshii: substrate selection achieved through multimerization

  Dóra K. Menyhárd , Anna Kiss-Szemán , Éva Tichy-Rács , Balázs Hornung , Krisztina Rádi , Zoltán Szeltner , Klarissza Domokos , Ilona Szamosi , Gábor Náray-Szabó , László Polgár , Veronika Harmat

  J Biol Chem (2013) 288(24):17884-17894. | DOI: 10.1074/jbc.M113.451534 | PMID: 23632025 Kivonat

• Helix compactness and stability: Electron structure calculations of conformer

  Imre Jákli , Szilárd N. Fejér , Ödön Farkas , Béla Viskolcz , Svend J. Knak Jensen , Imre G. Csizmadia , András Perczel

  Chem. Phys. Lett. (2013) 563:80-87. Kivonat

• Foldamer Stability Coupled to Aggregation Propensity of Elongated Trp-Cage Miniproteins

  Viktor Farkas , Barbara Csordás , Orsolya Hegyi , Gábor K. Tóth , András Perczel

  Eur. J. Org. Chem. (2013) 13:3513-3522. | DOI: 10.1002/ejoc.201300071 Kivonat

• Quantitative characterization of the activation steps of Mannan-Binding Lectin (MBL)-Associated Serine Proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway

  Márton Megyeri , Veronika Harmat , Balázs Major , Ádám Végh , Júlia Balczer , Dávid Héja , Katalin Szilágyi , Dániel Datz , Gábor Pál , Péter Závodszky , Péter Gál , József Dobó

  J Biol Chem (2013) 288(13):8922-8934. | DOI: 10.1074/jbc.M112.446500 | PMID: 23386610 Kivonat

• Structural insights into the Trp-cage folding intermediate formation

  Petra Rovó , Pál Stráner , András Láng , István Bartha , Kristóf Huszár , László Nyitray , András Perczel

  Chem. Eur. J. (2013) 19(8):2628-2640. | DOI: 10.1002/chem.201203764 | PMID: 23319425 Kivonat

• Star and Hyperbranched Polyisobutylenes via Terminally Reactive Polyisobutylene‐Polystyrene Block Copolymers

  Gergely Kali , Márta Szesztay , Andrea Bodor , Béla Iván

  Macromolecular Symposia (2013) 323(1), 37-41 | DOI: 10.1002/masy.201100116 Kivonat

2012

• Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2

  Dávid Héja , Veronika Harmat , Krisztián Fodor , Matthias Wilmanns , József Dobó , Péter Závodszky , Péter Gál , Gábor Pál

  J. Biol. Chem. (2012) 287(24):20290-300. doi: 10.1074/jbc.M112.354332 | PMID: 22511776 Kivonat

• Synthesis and preliminary structural and binding characterization of new enantiopure crown ethers containing an alkyl diarylphosphinate or a proton-ionizable diarylphosphinic acid unit

  György Székely , Barbara Csordás , Viktor Farkas , József Kupai , Péter Pogány , Zsuzsanna Sánta , Zoltán Szakács , Tünde Tóth , Miklós Hollósi , Péter Huszthy

  Eur. J. Org. Chem. (2012) 18:3396-3407. DOI: 10.1002/ejoc.201101769 Kivonat

• The role of entropy in initializing the aggregation of peptides: A first principle study on oligopeptide oligomerization

  Pohl G , Jákli I , Csizmadia IG , Papp D , Matías GF , Perczel A

  PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2012) 14:(4) pp. 1507-1516. Kivonat

• Exploiting diverse stereochemistry of b-amino acids: Toward a rational design of sheet-forming b-peptide systems

  Pohl G , Beke-Somfai T , Csizmadia IG , Perczel A

  AMINO ACIDS (2012) 43:(2) pp. 735-749. Kivonat

• Chemistry for life sciences

  Perczel A , Kiss T

  ACTUALITE CHIMIQUE &:( (2012) 360) p. A3. Kivonat

• Chemicalstability and structure –activity relationship studies of novelcyclic NGR peptides.

  MEZŐ G , ENYEDI K , CZAJLIK A , SZABÓ I , HEGEDÜS R , MAJER ZS , LAJKÓ E , KŐHIDA L , Perczel A

  University of Athens, Laboratory of Organic Chemistry, (2012) 2012. pp. 588-589.<br>(ISBN:978-960-466-121-3)

• Chemical stability and structure - activity relationship studies of novel cyclic NGR peptides

  MEZŐ G , Horvath R , Orgovan N , Kohidai L , LAJKÓ E , CZAJLIK A , Majer Z , Mihala N , Hegedues R , SZABÓ I , ENYEDI K , Perczel A

  JOURNAL OF PEPTIDE SCIENCE (2012) 18:(1) pp. S178-S179. Kivonat

• Variation of conformational properties at a glance. True graphical visualization of the Ramachandran surface topology as a periodic potential energy surface

  Jákli I , Knak Jensen SJ , Csizmadia IG , Perczel A

  CHEMICAL PHYSICS LETTERS (2012) 547: pp. 82-88. Kivonat

• Secondary structure of short β-peptides as the chiral expression of monomeric building units: A rational and predictive model

  Gorrea E , Pohl G , Nolis P , Celis S , Burusco KK , Branchadell V , Perczel A , Ortuño RM

  JOURNAL OF ORGANIC CHEMISTRY (2012) 77:(21) pp. 9795-9806. Kivonat

• Charged single alpha-helices in proteomes revealed by a consensus prediction approach

  Gáspári Z , Süveges D , Perczel A , Nyitray L , Tóth G

  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2012) 1824: pp. 637-646. Kivonat

• Kémlelni a láthatatlant: építőelemek, foldamerek, peptidek, és fehérjék

  Bodor Andrea , Farkas Viktor , Harmat Veronika , Jákli Imre , Karancsiné Menyhárd Dóra , Stráner Pál , Perczel András

  MAGYAR KÉMIAI FOLYÓIRAT - KÉMIAI KÖZLEMÉNYEK (2012) 118: pp. 159-167.

• Estimating intrinsic structural preferences of de novo emerging random-sequence proteins: Is aggregation the main bottleneck?

  Annamária F Ángyán , András Perczel , Zoltán Gáspári

  FEBS LETTERS (2012) 586: pp. 2468-2472. Kivonat

2011

• Crystallization and preliminary crystallographic analysis of dUTPase from the φ11 helper phage of Staphylococcus aureus

  Ibolya Leveles , Gergely Róna , Imre Zagyva , Ábris Ádám Bendes , Veronika Harmat , Beáta G. Vértessy

  Acta Crystallogr Sect F Struct Biol Cryst Commun. (2011) 67(Pt 11):1411-1413. | DOI: 10.1107/S1744309111034580 | PMID: 22102244 Kivonat

• Freezing effect on chirality amplification of L-asparagine by crystallization of the racemate in preferential condition

  Tamás Vajda , Miklós Hollósi

  CRYOLETTERS (2011) 32: 447-450 | PMID: 22227704 Kivonat

• Suzuki-Miyaura cross-coupling reactions of halo derivatives of 4H-pyrido[1,2-a]pyrimidin-4-ones

  Annamária Molnár , Anita Kapros , László Párkányi , Zoltán Mucsi , Gábor Vlád , István Hermecz

  Org Biomol Chem (2011) 9(19):6559-6565. DOI: 10.1039/c1ob05505d PMID: 21808806 Kivonat

• Transformation of aldose formazans. Novel synthesis of 2-acetamido-2-deoxypentonolactones and a new pent-2-enose formazan.

  Zsoldos-Mády V , Pintér I , Peredy-Kajtár M , Perczel A

  Carbohydr Res (2011) 346(12):1534-1540. DOI: 10.1016/j.carres.2011.04.026 PMID: 21592466 Corrigendum: Carbohydr Res (2011) 346(17): 2823. Kivonat

• Cooperativity network of Trp-cage miniproteins: probing salt-bridges

  Petra Rovó , Viktor Farkas , Orsolya Hegyi , Orsolya Szolomájer-Csikós , Gábor K. Tóth , András Perczel

  J Pept Sci (2011) 17(9):610-619. DOI: 10.1002/psc.1377 PMID: 21644245 Kivonat

• Directed evolution reveals the binding motif preference of the LC8/DYNLL hub protein and predicts large numbers of novel binders in the human proteome

  Péter Rapali , László Radnai , Dániel Süveges , Veronika Harmat , Ferenc Tölgyesi , Weixiao Y. Wahlgren , Gábor Pál

  PLoS One (2011) 6(4):e18818. | DOI: 10.1371/journal.pone.0018818 | PMID: 21533121 Kivonat

• Structure and catalysis of acylamonoacyl peptidase: closed and open subunits of a dimer oligopeptidase

  Veronika Harmat , Klarissza Domokos , Dóra K. Menyhárd , Anna Palló , Zoltán Szeltner , Ilona Szamosi , Tamás Beke , Gábor Náray-Szabó , László Polgár

  Journal of Biological Chemistry (2011) 286:1987-1998. PMID: 21084296 | DOI: 10.1074/jbc.M110.169862 Kivonat

• Erratum: Transformation of aldose formazans. Novel synthesis of 2-acetamido-2-deoxypentonolactones and a new pent-2-enose formazan (Carbohydrate Research (2011) 346 (1534-1540))

  Zsoldos-Mády V , Pintér I , Peredy-Kajtár M , Perczel A

  CARBOHYDRATE RESEARCH (2011) 346:(17) p. 2823. Kivonat

• Zn(2+)-induced rearrangement of the disordered TPPP/p25 affects its microtubule assembly and GTPase activity.

  Zotter A , Oláh J , Hlavanda E , Bodor A , Perczel A , Szigeti K , Fidy J , Ovádi J

  BIOCHEMISTRY (2011) 50:(44) pp. 9568-9578. Kivonat

• Disordered TPPP/P25 Binds GTP and Displays Mg(2+)-Dependent Gtpase Activity.

  Zotter A , Bodor A , Oláh J , Hlavanda E , Orosz F , Perczel A , Ovádi J

  FEBS LETTERS (2011) 585:(5) pp. 803-808. Kivonat

• Hyperfine-Shifted (13)C Resonance Assignments in an Iron-Sulfur Protein with Quantum Chemical Verification: Aliphatic C-H center dot center dot center dot S 3-Center-4-Electron Interactions

  Westler WM , Lin IJ , Perczel A , Weinhold F , Markley JL

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011) 133:(5) pp. 1310-1316.

• Full backbone assignment and dynamics of the intrinsically disordered dehydrin ERD14.

  Szalainé Ágoston B , Kovács D , Tompa P , Perczel A

  BIOMOLECULAR NMR ASSIGNMENTS (2011) 5:(2) pp. 189-193. Kivonat

• New Small-Size Antifungal Peptides: Design, Synthesis and Antifungal Activity

  Garro AD , Garibotto FM , Rodriguez AM , Raimondi M , Zacchino SA , Perczel A , Somlai C , Penke B , Enriz RD

  LETTERS IN DRUG DESIGN AND DISCOVERY (2011) 8:(6) pp. 562-567. Kivonat

• Penetratin analogues acting as antifungal agents

  Francisco M Garibotto , Adriana D. Garro , Ana M. Rodríguez , Marcela Raimondi , Susana A. Zacchino , András Perczel , Csaba Somlai , Botond Penke , Ricardo D. Enriz

  Eur. J. Med. Chem. (2011) 46(1):370-377. | DOI: 10.1016/j.ejmech.2010.10.025. | PMID: 21093119 Kivonat

• Local Protein Backbone Folds Determined by Calculated NMR Chemical Shifts

  András Czajlik , Ilona Hudáky , András Perczel

  JOURNAL OF COMPUTATIONAL CHEMISTRY (2011) 32:(16) pp. 3362-3382.

2010

• Interaction between separated consecutive complement control modules of human C1r: implications for dimerization of the full-length protease.

  András Láng , Balázs Major , Katalin Szilágyi , Zoltán Gáspári , Péter Gál , Péter Závodszky , András Perczel

  FEBS Lett. (2010) 584(22):4565-4569. | DOI: 10.1016/j.febslet.2010.10.033 | PMID: 20970424 Kivonat

• Protein dynamics as reported by NMR

  Zoltán Gáspári , András Perczel

  Annu. Rep. NMR (2010) Vol. 71, in press

• Detecting atypical examples of known domain types by sequence similarity searching: The SBASE domain library approach

  Somdutta Dhir , Mircea Pacurar , Dino Franklin , Zoltán Gáspári , Attila Kertész-Farkas , Frank Eisenhaber , Sándor Pongor

  Curr. Protein Pept. Sci. (2010) 11(7):538-549. | DOI: 10.2174/138920310794109148 | PMID: 20887262 Kivonat

• Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase

  Ildikó Pécsi , Ibolya Leveles , Veronika Harmat , Beáta G. Vértessy , Judit Tóth

  Nucleic Acids Res. (2010) 38(20):7179-7186. | DOI: 10.1093/nar/gkq584 | PMID: 20601405 Kivonat

• CoNSEnsX: an ensemble view of protein structures and NMR-derived experimental data

  András Perczel , Annamária F. Ángyán , Balázs Szappanos , Zoltán Gáspári

  BMC Structural Biology (2010) 10:39. | DOI: 10.1186/1472-6807-10-39. | PMID: 21034466 Kivonat

• Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r

  András Láng , Katalin Szilágyi , Balázs Major , Péter Gál , Péter Závodszky , András Perczel

  FEBS J. (2010) 277(19):3986-3998. | DOI: 10.1111/j.1742-4658.2010.07790.x | PMID: 20796027 Kivonat

• Structure and mechanism of calmodulin binding to a signaling sphingolipid reveal new aspects of lipid-protein interactions

  Erika Kovács , Veronika Harmat , Judit Tóth , Beáta G. Vértessy , Károly Módos , József Kardos , Károly Liliom

  FASEB J. (2010) 24(10):3829-39. | DOI: 10.1096/fj.10-155614 | PMID: 20522785 Kivonat

• New antifungal peptides. Synthesis, bioassays and initial structure prediction by CD spectroscopy

  Mónica S. Olivella , Ana M. Rodríguez , Susana A. Zacchino , Csaba Somlai , Botond Penke , Viktor Farkas , András Perczel , Ricardo D. Enriz

  Bioorg. Med. Chem. Lett. (2010) 20(16):4808-4011. | DOI: 10.1016/j.bmcl.2010.06.105. | PMID: 20620056 Kivonat

• Extended apolar β-peptide foldamers: the role of axis chirality on β-peptide sheet stability

  Gábor Pohl , Tamás Beke , Imre G. Csizmadia , András Perczel

  J. Phys. Chem. B (2010) 114(29):9338-9348. | DOI: 10.1021/jp100955u. | PMID: 20666395 Kivonat

• Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases

  Enikő Takács , Ibolya Leveles , Veronika Harmat , Anna Lopata , Judit Tóth , Beáta G. Vértessy

  FEBS Lett. (2010) 584(14):3047-54. | DOI: 10.1016/j.febslet.2010.05.018 | PMID: 20493855 Kivonat

• Folded-unfolded cross-predictions and protein evolution: the case study of coiled-coils

  Balázs Szappanos , Dániel Süveges , László Nyitray , András Perczel , Zoltán Gáspári

  FEBS Lett. (2010) 584(8):1623-1627. | DOI: 10.1016/j.febslet.2010.03.026. | PMID: 20303956 Kivonat

• Stability of the hydration layer of tropocollagen: A QM study

  Villő K. Pálfi , András Perczel

  J. Comput. Chem. (2010) 31(4):764-777. | DOI: 10.1002/jcc.21361. | PMID: 19569200 Kivonat

• Reconciling the lock-and-key and dynamic views of canonical serine protease inhibitor action

  Zoltán Gáspári , Péter Várnai , Balázs Szappanos , András Perczel

  FEBS Lett. (2010) 584(1):203-206. | DOI: 10.1016/j.febslet. | PMID: 19932101 Kivonat

• Probing dynamic protein ensembles with atomic proximity measures

  Zoltán Gáspári , Annamária F. Ángyán , Somdutta Dhir , Dino Franklin , András Perczel , Alessandro Pintar , Sándor Pongor

  Curr. Protein Pept. Sci. (2010) 11(7):515-522. | DOI: 10.2174/138920310794109201 | PMID: 20887264 Kivonat

2009

• Biophysical studies of the membrane location of the voltage-gated sensors in the HsapBK and KvAP K⁺ channels.

  Henrik Biverståhl , Jesper Lind , Andrea Bodor , Lena Mäler

  Biochem. Biophys. Acta (2009) 1788:1976-1986 Kivonat

• Characterization of a novel acylaminoacyl peptidase with hexameric structure and endopeptidase activity

  Zoltán Szeltner , András L. Kiss , Klarissza Domokos , Veronika Harmat , Gábor Náray-Szabó , László Polgár

  Biochem. Biophys. Acta (2009) 1794:1204-1210 Kivonat

• MASP-1, a Promiscuous Complement Protease: Structure of Its Catalytic Region Reveals the Basis of Its Broad Specificity

  József Dobó , Veronika Harmat , László Beinrohr , Edina Sebestyén , Péter Závodszky , Péter Gál

  J. Immunol. (2009) 183:1207-1214. Kivonat

• Theoretical aspects of molecular recognition.

  Veronika Harmat , Gábor Náray-Szabó

  Croat. Chem. Acta (2009) 82:277-282.

• Chiral and achiral fundamental conformational building units of β-peptides: a matrix isolation conformational study on Ac-β-HGly-NHMe and Ac-β-HAla-NHMe

  Tamás Beke , Csaba Somlai , Gábor Magyarfalvi , András Perczel , György Tarczay

  J. Phys. Chem. B (2009) 113:7918-7926 Kivonat

• The inherent flexibility of peptides and protein fragments quantitized by CD in conjunction with CCA+

  Imre Jákli , András Perczel

  J. Pept. Sci. (2009) 15:738-752. Kivonat

• Combined NMR three-bond scalar coupling measurements and QM calculations to calculate OH-rotamer equilibrium of polyalcohols

  Katalin E. Kövér , Tamás Beke , András Lipták , András Perczel

  J. Comput. Chem. (2009) 30:540-550. Kivonat

• Functional Aspects of the Solution Structure and Dynamics of PAF, a Highly Stable Antifungal Protein from Penicillium chrysogenum

  Gyula Batta , Herbert Lindner , István Pócsi , Nikoletta Hegedüs , Éva Leiter , Andrea Eigentler , Anil Kumar Chhillar , Lydia Kaiserer , Bettina Sarg , Ulrike Binder , Katalin E. Kövér , Szabolcs Sándor , Zoltán Gáspári , Teréz Barna , Florentine Marx

  FEBS J. (2009) 276:2875-2890. Kivonat

• Charged single α-helix: a versatile protein structural motif

  Dániel Süveges , Zoltán Gáspári , Gábor Tóth , László Nyitray

  Proteins (2009) 74:905-916. Kivonat

• Calmodulin in Complex with Proteins and Small Molecule Ligands: Operating with the Element of Surprise; Implications for Structure-Based Drug Design

  Dóra K. Menyhárd , György M. Keserű , Gábor Náray-Szabó

  Current Computer-Aided Drug Design (2009) 5(4), 264 - 279 | doi: 10.2174/157340909789577874 Kivonat

2008

• Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules

  Károly Kánai , Péter Arányi , Zsolt Böcskei , György Ferenczy , Veronika Harmat , Kálmán Simon , Sándor Bátori , Gábor Náray-Szabó , István Hermecz

  J Med Chem. (2008) 51(23):7514-7522. | DOI: 10.1021/jm800944x | PMID: 19006380 Kivonat

• Purification, crystallization and preliminary X-ray analysis of human mannose-binding lectin-associated serine protease-1 (MASP-1) catalytic region

  József Dobó , Veronika Harmat , Edina Sebestyén , László Beinrohr , Péter Závodszky , Péter Gál

  Acta Crystallogr Sect F Struct Biol Cryst Commun. (2008) 64(Pt 9):781-784. | DOI: 10.1107/S174430910802294X | PMID: 18765903 Kivonat

• Structural and kinetic contributions of the oxyanion binding site to the catalytic activity of acylaminoacyl peptidase

  András L. Kiss , Anna Palló , Gábor Náray-Szabó , Veronika Harmat , László Polgár

  J Struct Biol. (2008) 162(2):312-323. | DOI: 10.1016/j.jsb.2008.01.012 | PMID: Kivonat

• Cooperation between a salt bridge and the hydrophobic core triggers fold stabilization in a Trp-cage miniprotein

  Péter Hudáky , Pál Stráner , Viktor Farkas , Györgyi Váradi , Gábor Tóth , András Perczel

  Biochemistry (2008) 47(3):1007-1016. DOI: 10.1021/bi701371x PMID: 18161949 Kivonat

• Local structural preferences of calpastatin, the intrinsically unstructured protein inhibitor of calpain

  Róbert Kiss , Dénes Kovács , Péter Tompa , András Perczel

  Biochemistry (2008) 47:6936-6945. Kivonat

• A redesigned genetic code for selective labeling in protein NMR

  Zoltán Gáspári , Gábor Pál , András Perczel

  BioEssays (2008) 30:772-780. Kivonat

• Structure and stability of short β-peptide nanotubes: a non-natural representative of collagen?

  András Czajlik , Tamás Beke , Andrea Bottoni , András Perczel

  J. Phys. Chem. B (2008) 112:7956-7966. Kivonat

• Intrinsic structural disorder of DF31, a Drosophila protein of chromatin decondensation and remodeling activities

  Edit Szőllősi , Mónika Bokor , Andrea Bodor , András Perczel , Éva Klement , Katalin F. Medzihraszky , Kálmán Tompa , Péter Tompa

  J. Proteome Res. (2008) 7:2291-2299. Kivonat

• Calcium-induced tripartite binding of intrinsically disordered calpastatin to its cognate enzyme, calpain

  Róbert Kiss , Zoltán Bozóky , Dénes Kovács , Gergely Róna , Péter Friedrich , Péter Dvortsák , Rudinger Weisemann , Péter Tompa , András Perczel

  FEBS Lett. (2008) 582:2149-2154. Kivonat

• Antibody recognition and conformational flexibility of a plaque-Specific β-amyloid epitope modulated by non-native peptide flanking regions

  Marilena Manea , Michael Przybylski , András Perczel , Ödön Farkas , Anikó Horváth , Andrea Bodor , Kata Horváti , Gábor Mező , Adrián Kalászi , Ferenc Hudecz

  J. Med. Chem. (2008) 51:1150-1161 Kivonat

• The mechanism of the reverse recovery step, phosphate release, and actin activation of Dictyostelium myosin II

  Máté Gyimesi , Bálint Kintses , Andrea Bodor , András Perczel , Stefan Fischer , Clive R. Bagshaw , András Málnási-Csizmadia

  J. Biol. Chem. (2008) 283:8153-8163. Kivonat

• A theoretical comparison of self-assembling α- and β-peptide nanostructures: toward design of β-barrel frameworks.

  Tamás Beke , András Czajlik , Balázs Bálint , András Perczel

  ACS Nano (2008) 2:545-553. Kivonat

• How stable is a collagen triple helix? An ab initio study on various collagen and beta-sheet forming sequences

  Villő Pálfi , András Perczel

  J. Comput. Chem. (2008) 29:1374-1386 Kivonat

• A matrix isolation study on Ac-L-Pro-NH₂, a frequent structural element of β- and γ-turns of peptides and proteins

  Gábor Pohl , András Perczel , Elemér Vass , Gábor Magyarfalvi , György Tarczay

  Tetrahedron (2008) 64(9):2126-2133. Kivonat

• Distribution and evolution of short tandem repeats in closely related bacterial genomes

  Edit Kassai-Jáger , Csaba Ortutay , Gábor Tóth , Tibor Vellai , Zoltán Gáspári

  Gene (2008) , 410(1):18-25. Kivonat

• Fast protein fold estimation from NMR-derived distance restraints

  Annamária F. Ángyán , András Perczel , Sándor Pongor , Zoltán Gáspári

  Bioinformatics (2008) 24(2):272-275. Kivonat

• The prolylproline unit in model peptides and in fragments from databases

  Ilona Hudáky , András Perczel

  Proteins (2008) 70(4):1389-1407. Kivonat

• Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r

  József Kardos , Péter Závodszky , Yuji Goto , Gábor Náray-Szabó , László Gráf , Katalin Szilágyi , Orsolya Barabás , Anna Palló , Veronika Harmat , Péter Gál

  Mol. Immunol. (2008) 45(6):1752-1760 Kivonat

2007

• Dead-end street of protein folding: thermodynamic rationale of amyloid fibril formation

  András Perczel , Péter Hudáky , Villő Pálfi

  J. Am. Chem. Soc. (2007) , 129(48):14959-14965 Kivonat

• pK_a optimized catalysis in serine proteinases, an ab initio study on the catalaytic His

  Péter Hudáky , András Perczel

  Int. J. Quantum Chem. (2007) 107(11):2178-2183 Kivonat

• A matrix isolation study on Ac-Gly-NHMe and Ac-L-Alai-NHMe, the simplest chiral and achiral building blocks of peptides and proteins

  Gábor Pohl , András Perczel , Elemér Vass , Gábor Magyarfalvi , György Tarczay

  Phys. Chem. Chem. Phys. (2007) 9:4698-4708. Kivonat

• Information accumulation in helical oligopeptide structures

  Béla Viskolcz , Szilárd N. Fejér , Svend J. Knak Jensen , András Perczel , Imre G. Csizmadia

  Chem. Phys. Lett. (2007) 450: 123-126. Kivonat

• Quantum mechanical studies on the existence of a trigonal bipyramidal phosphorane intermediate in enzymatic phosphate ester hydrolysis

  Imre Berente , Tamás Beke , Gábor Náray-Szabó

  Theor. Chem. Acc. (2007) 118:129-134 Kivonat

• Major human γ-aminobutyrate transporter: In silico prediction of substrate efficacy

  Anna Palló , Ákos Bencsura , László Héja , Tamás Beke , András Perczel , Julianna Kardos , Ágnes Simon

  Biochem. Biophy. Res. Commun. (2007) Kivonat

• A new synthetic method for the preparation of star-shaped polyisobutylene with hyperbranched polystyrene core

  Gergely Kali , Márta Szesztay , Andrea Bodor , Béla Iván

  Macromol. Chem. Phys. (2007) 208: 1388-1393. Kivonat

• Homogeneous gold-catalyzed hydrosilylation of aldehydes

  Diána Lantos , Marıa Contelb , Sergio Sanzb , Andrea Bodor , István T. Horváth

  J. Organomet. Chem. (2007) 692: 1799-1805 Kivonat

• Imidazolium ionic liquids as solvents for cerium(IV)-mediated oxidation reactions

  Hasan Mehdi , Andrea Bodor , Diána Lantos , István T. Horváth , Dirk E. De Vos , Koen Binnemans

  J. Org. Chem. (2007) 72: 517-524. Kivonat

• Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins

  Veronika Németh-Pongrácz , Emese Kónya , Katalin F. Medzihradszky , Éva Hunyadi-Gulyás , Éva Klement , Veronika Harmat , Maxim Petoukhov , Dmitri Svergun , Helena Zábranská , Michalea Rumlová , Iva Pichová , István Simon , Mónika Fuxreiter , Orsolya Barabás , Beáta G. Vértessy

  Nucleic Acids Res. (2007) , 35: 495-505. Kivonat

• The acylaminoacyl peptidase from Aeropyrum pernix K1 thought to be an exopeptidase displays endopeptidase activity

  András L. Kiss , Balázs Hornung , Krisztina Rádi , Zsolt Gengeliczki , Bálint Sztáray , Tünde Juhász , Zoltán Szeltner , Veronika Harmat , László Polgár

  J. Mol. Biol. (2007) 368: 509-520. Kivonat

• C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease

  László Beinrohr , Veronika Harmat , József Dobó , Zsolt Lörincz , Péter Gál , Péter Závodszky

  J. Biol. Chem. (2007) 282: 21100-21109. Kivonat

• Divergent microsatellite evolution in the human and chimpanzee lineages

  Zoltán Gáspári , Csaba Ortutay , Gábor Tóth

  FEBS Lett. (2007) 581(13):2523-2526. Kivonat

• When the surface tells what lies beneath: Combinatorial phage-display mutagenesis reveals complex network of surface-core interactions in the pacifastin protease inhibitor family

  Borbála Szenthe , András Patthy , Zoltán Gáspári , Adrienna Katalin Kékesi , László Gráf , Gábor Pál

  J. Mol. Biol. (2007) 370(1):63-79. Kivonat

• Structure, enzymatic stability and antitumor activity of sea lamprey GnRH-III and its dimer derivatives

  Gábor Mező , András Perczel , Michael Przybylski , Magdolna Kovács , Orsolya Csuka , Borbála Vincze , Marian Boldizsár , Bence Kapuvári , Andrea Bodor , Elemér Vass , Zsuzsa Majer , Viktor Farkas , Annamária Jakab , Marilena Manea , András Czajlik , Ferenc Hudecz

  Peptides (2007) 28(4): 806-820 Kivonat

• Determining the molecular basis for the pH-dependent interaction between the Link module of human TSG-6 and hyaluronan

  Charles D. Blundell , David J. Mahoney , Martin R. Cordell , Andrew Almond , Jan D. Kahmann , András Perczel , Jonathan D. Taylor , Iain D. Campbell , Anthony J. Day

  J. Biol. Chem. (2007) , 282:12976-12988. Kivonat

• Modeling-based characterization of the elicitor function of amino acid 461 of Cucumber mosaic virus 1a protein in the hypersensitive response

  Katalin Salánki , Ákos Gellért , Gábor Náray-Szabó , Ervin Balázs

  Virology (2007) 358: 109-118. Kivonat

• A combined electronegativity equalization and electrostatic potential fit method for the determination of atomic point charges

  Imre Berente , Eszter Czinki , Gábor Náray-Szabó

  J. Comput. Chem. (2007) 28: 1936-1942. Kivonat

• A Protein Classification Benchmark collection for machine learning

  Paolo Sonego , Mircea Pacurar , Somdutta Dhir , Attila Kertész-Farkas , András Kocsor , Zoltán Gáspári , Jack Leunissen , Sándor Pongor

  Nucleic Acids Res. (2007) , 35(Database issue):D232-D236. Kivonat

• Freezing effect on chirality generation of DL-alanine-N-carboxy-anhydride oligomerization in aqueous solution

  Tamás Vajda , Miklós Hollósi

  Protein Pept. Lett. (2007) 14(9):854-858. | DOI: http://dx.doi.org/10.2174/092986607782110275 | PMID: 18045225 Kivonat

2006

• Enzyme:substrate hydrogen bond shortening during the acylation phase of serine protease catalysis

  Krisztián Fodor , Veronika Harmat , Richard Neutze , László Szilágyi , László Gráf , Gergely Katona

  Biochemistry (2006) 45(7):2114-2121. | 10.1021/bi0517133 | PMID: 16475800 Kivonat

• Prediction of folding preference of 10kDa silk-like proteins using a lego-approach and ab initio calculations

  Gábor Pohl , Tamás Beke , János Borbély , András Perczel

  J. Am. Chem. Soc. (2006) , 128:14548-14559 Kivonat

• Alternatively spliced exon B of myosin Va is essential for binding the tail-associated light chain shared by dynein

  Zsuzsa Hódi , Attila L. Németh , László Radnai , Csaba Hetényi , Katalin Schlett , Andrea Bodor , András Perczel , László Nyitray

  Biochemistry (2006) 45:12582-12595. Kivonat

• Theoretical study on tertiary structural elements of β-peptides: Nanotubes formed from parallel-sheet-derived assemblies of β-peptides

  Tamás Beke , Imre G. Csizmadia , András Perczel

  J. Am. Chem. Soc. (2006) 128:5158-5167. Kivonat

• Local binding with globally distributed changes in a small protease inhibitor upon enzyme binding

  Zoltán Gáspári , Borbála Szenthe , András Patthy , William M. Westler , László Gráf , András Perczel

  FEBS J. (2006) 273:1831-1842. Kivonat

• Determining suitable lego-structures to estimate stability of larger nanostructures using computational methods

  Tamás Beke , András Czajlik , Imre G. Csizmadia , András Perczel

  Phys. Biol. (2006) 3:S26-S39. Kivonat

• Toward a rational design of β-peptide structures.

  Tamás Beke , Csaba Somlai , András Perczel

  J. Comput. Chem. (2006) 27:20-38. Kivonat

• A self-stabilized model of the chymotrypsin catalytic pocket. The energy profile of the overall catalytic cycle

  Péter Hudáky , András Perczel

  Proteins (2006) 62:749-759. Kivonat

2005

• Structural evidence for non-canonical binding of Ca2+ to a canonical EF-hand of a conventional myosin

  Judit É. Debreczeni , László Farkas , Veronika Harmat , Csaba Hetényi , István Hajdú , Péter Závodszky , László Nyitray , Kazuhiro Kohama

  J. Biol. Chem. (2005) 280(50):41458-41464. | PMID: 16227209 Kivonat

• A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations

  Péter Gál , Andrea Kocsis , Tünde Bián , Veronika Harmat , László Barna , Géza Ambrus , Barbara Végh , Robert B. Sim , Péter Závodszky , Gábor Náray-Szabó

  J. Biol. Chem. (2005) 280(39):33435-33444. | PMID: 16040602 Kivonat

• The structure of the complex of calmodulin with KAR-2: a novel mode of binding explains the unique pharmacology of the drug

  István Horváth , Veronika Harmat , András Perczel , Villő Pálfi , László Nyitray , Attila Nagy , Emma Hlavanda , Gábor Náray-Szabó , Judit Ovádi

  J. Biol. Chem. (2005) 280(9):8266-8274. | PMID: 15596444 Kivonat

• Peptide models XLV: Conformational properties of N-formyl-L-methioninamide and its relevance to methionine in proteins

  András Láng , Imre G. Csizmadia , András Perczel

  Proteins (2005) 58(3):571-588. | DOI: 10.1002/prot.20307 | PMID: 15616985 Kivonat

• Surprisingly great difference in reactivity depending upon the ring size: solvolysis and molecular structure study of some N-trimethylsilylated cyclic ureas

  Roland Szalay , Gábor Pongor , Veronika Harmat , Zsolt Böcskei , Dezső Knausz

  Journal of Organometallic Chemistry (2005) 690(6), 1498–1506 | doi:10.1016/j.jorganchem.2004.12.023 Kivonat

• Investigation of penetratin peptides. Part 2. In vitro uptake of penetratin and two of its derivatives

  Tamás Letoha , Ferenc Peták , András Czajlik , Ernő Duda , Erzsébet Kusz , Hristos Glavinas , Zsolt Venkei , Csaba Somlai , Szilvia Gaál , Botond Penke

  J. Pept. Sci. (2005) 11:805-811. Kivonat

• Efficient recognition of folds in protein 3-D structures by the improved PRIDE algorithm.

  Zoltán Gáspári , Kristian Vlahovicek , Sándor Pongor

  Bioinformatics (2005) 21:3322-3323. Kivonat

• Toward direct determination of conformations of protein building units from multidimensional NMR experiments VI. Chemical shift analysis of His to gain 3D structure and protonation state information

  Péter Hudáky , András Perczel

  J. Comput. Chem. (2005) 26:1307-1317. Kivonat

• Structure and stability of β-pleated sheets.

  András Perczel , Zoltán Gáspári , Imre G. Csizmadia

  J. Comput. Chem. (2005) 26:1155-1168. Kivonat

• Extended intermolecular interactions in a serine protease canonical inhibitor complex account for strong and highly specific inhibition

  Krisztián Fodor , Veronika Harmat , Csaba Hetényi , József Kardos , József Antal , András Perczel , András Patthy , Gergely Katona , László Gráf

  J. Mol. Biol. (2005) 350:156-169. Kivonat

• Solution state conformation and degradation of cyclopeptides containing an NGR motif

  Anna K. Füzéry , Nikolett Mihala , Pál Szabó , András Perczel , Raffaella Giavazzi , Helga Süli-Vargha

  J. Pept. Sci. (2005) 11(1):53-59. Kivonat

2004

• The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions

  Veronika Harmat , Péter Gál , József Kardos , Katalin Szilágyi , Géza Ambrus , Gábor Náray-Szabó , Péter Závodszky

  J. Mol. Biol. (2004) 342(5):1533-1546. | PMID: 15364579 Kivonat

• Potential energy curves, surfaces and hypersurfaces. A model to follow and understand the conformational transformations in amino acids.

  András Láng , Anna K. Füzéry , Tamás Beke , Péter Hudáky , András Perczel

  J. Mol. Struct. (THEOCHEM) (2004) 675(1-3):163-175. | http://dx.doi.org/10.1016/j.theochem.2003.12.047 Kivonat

• Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies

  Gábor G. Kovács , Herbert Budka , Ellen Gelpi , Attila Lehotzky , László Tirián , Anna Erdei , Gábor Mező , Ferenc Hudecz , András Perczel , Tamás Molnár , Gerg Botond , Evo Lindersson , Poul Henning Jensen , János Kovács , Lajos László , Judit Ovádi

  Neurobiol Dis. (2004) 17(2):155-162. Kivonat

• Conformation dependence of pK_a: ab initio and DFT investigation of histidine

  Péter Hudáky , András Perczel

  J. Phys. Chem. A (2004) 108(29):6195-6205. Kivonat

• Solvation model induced structural changes in peptides. A quantum chemical study on Ramachandran surfaces and conformers of alanine diamide using the polarizable continuum model

  Ilona Hudáky , Péter Hudáky , András Perczel

  J. Comput. Chem. (2004) 25(12):1522-1531. Kivonat

• Stability issues of covalently and noncovalently bonded peptide subunits

  András Perczel , Péter Hudáky , Anna K. Füzéry , Imre G. Csizmadia

  J. Comput. Chem. (2004) 25(8):1084-1100. Kivonat

• Peptide Models XXXII. Computed chemical shift analysis of penetratin fragments

  András Czajlik , András Perczel

  J. Mol. Struct. (THEOCHEM) (2004) 675(1-3): 129-139. Kivonat

• Peptide models XLII. Ab initio study on conformational changes of N-formyl--histidinamide caused by protonation or deprotonation of its side chain.

  Péter Hudáky , András Perczel

  J. Mol. Struct. (THEOCHEM) (2004) 675(1-3): 117-127. Kivonat

• A nomenclature of peptide conformers.

  Ilona Hudáky , Róbert Kiss , András Perczel

  J. Mol. Struct. (THEOCHEM) (2004) 675(1-3): 177-183. Kivonat

• Is there an excuse for the non-conformist? Notes on the calculated energies, atom-atom contacts and natural abundance of the different conformers of alanine in proteins.

  Zoltán Gáspári , Ilona Hudáky , András Czajlik , András Perczel

  J. Mol. Struct. (THEOCHEM) (2004) 675(1-3): 141-148. Kivonat

• Binding crevice for TT-232 in a homology model of type 1 somatostatin receptor

  Ágnes Simon , András Czajlik , András Perczel , György Kéri , Lajos Nyikos , Zsuzsa Emri , Julianna Kardos

  Biochem. Biophys. Res. Commun. (2004) , 316(4):1059-1064. Kivonat

• Multidimensional NMR identifies the conformational shift essential for catalytic competence in the 60 KDA Drosophila melanogaster dUTPase trimer

  Zsófia Dubrovay , Zoltán Gáspári , Éva Hunyadi-Gulyás , Katalin F. Medzihradszky , András Perczel , Beáta G. Vértessy

  J. Biol. Chem. (2004) , 279(17): 17945-17950. Kivonat

• On the flexibility of β-peptides

  Tamás Beke , Imre G. Csizmadia , András Perczel

  J. Comput. Chem. (2004) 25:285-307. Kivonat

• Vicinal disulfide bridge conformers by experimental methods and by ab initio and DFT molecular computations

  Ilona Hudáky , Zoltán Gáspári , Oliviero Carugo , Masa Cemazar , Sándor Pongor , András Perczel

  Proteins (2004) 55(1): 152-168. Kivonat

• Same fold with different mobility: backbone dynamics of small protease inhibitors from the desert locust, Schistocerca gregaria

  Borbála Szenthe , Zoltán Gáspári , Attila Nagy , András Perczel , László Gráf

  Biochemistry (2004) , 43(12): 3376-3384. Kivonat

• A simple fold with variations: the pacifastin inhibitor family

  Zoltán Gáspári , Csaba Ortutay , András Perczel

  Bioinformatics (2004) 20(4):448-451. Kivonat

2003

• A conformational comparison of N- and C-protected methionine and N- and C-protected homocysteine

  András Láng , Krisztina György , Imre G. Csizmadia , András Perczel

  J. Mol. Struct. (THEOCHEM) (2003) 666–667:219–241. | http://dx.doi.org/10.1016/j.theochem.2003.08.029 Kivonat

• Lipophilicity of aminopyridazinone regioisomers

  Massud A. S. Anwair , László Károlyházy , Diána Szabó , Balázs Balogh , István Kövesdi , Veronika Harmat , Judit Krenyácz , Ákos Gellért , Krisztina Takács-Novák , Péter Mátyus

  J Agric Food Chem. (2003) 51(18):5262-5270. | DOI: 10.1021/jf0343938 | PMID: 12926868 Kivonat

• Membrane translocation of penetratin and its derivatives in different cell lines.

  Tamás Letoha , Sándor Gaál , Csaba Somlai , András Czajlik , András Perczel , Botond Penke

  J. Mol. Recognit. (2003) 16(5):272-279. Kivonat

• Synthesis, solution structure analysis and antibody binding of cyclic epitope peptides from glycoprotein D of Herpes simplex virus type I.

  Gitta Schlosser , Sytske Welling-Wester , Szilvia Bõsze , András Perczel , Matty Feijlbrief , Zsuzsa Majer , Elemér Vass , Róbert Kiss , Gábor Mező , Ferenc Hudecz

  Biophys. Chem. (2003) 106(2):155-171. Kivonat

• Intrinsically stable secondary structure elements of proteins: a comprehensive study of folding units of proteins by computation and by analysis of data determined by X-ray crystallography

  András Perczel , Imre Jákli , Imre G. Csizmadia

  Chem. Eur. J. (2003) 9(21): 5332-5342 Kivonat

• Vicinal disulfide turns

  Oliviero Carugo , Masa Cemazar , Sotir Zahariev , Ilona Hudáky , Zoltán Gáspári , András Perczel , Sándor Pongor

  Protein Eng. (2003) 16(9): 637-639. Kivonat

• Structure-oriented rational design of chymotrypsin inhibitor models

  Zoltán Mucsi , Zoltán Gáspári , György Orosz , András Perczel

  Protein Eng. (2003) 16(9): 673-681. Kivonat

• Toward direct determination of conformations of protein building units from multidimensional NMR experiments. V. NMR chemical shielding analysis of N-formyl-serinamide, a model for polar side-chain containing peptides

  András Perczel , Anna K. Füzéry , Attila G. Császár

  J. Comput. Chem. (2003) 24(10): 1157-1171. Kivonat

• A theoretical case study of type I and type II β-turns

  Eszter Czinki , Attila G. Császár , András Perczel

  Chem Eur J (2003) 9(5): 1182-1191 Kivonat

• Cryo-bioorganic chemistry: freezing effect on stereoselection of L- and DL- alanine-N-carboxyanhydride oligomerization in dioxane solution

  Tamás Vajda , Miklós Hollósi , Marianna Mák

  CRYOLETTERS (2003) CRYOLETTERS 24: 253-259 | PMID: 12955172 Kivonat

2002

• Investigation of penetratin peptides. Part 1. The environment dependent conformational properties of penetratin and two of its derivatives.

  András Czajlik , Eszter Meskó , Botond Penke , András Perczel

  J. Pept. Sci. (2002) 8(4):151-171. Kivonat

• Comparative structure analysis of proteinase inhibitors from the desert locust, Schistocerca gregaria

  Zoltán Gáspári , András Patthy , László Gráf , András Perczel

  Eur J Biochem. (2002) 269(2): 527-537. Kivonat

• Protonated and deprotonated N-Formyl-L-histidinamide:an ab-initio study on side-chain potential energy surfaces of all major backbone conformers

  Péter Hudáky , Ilona Hudáky , András Perczel

  J. Mol. Struct. (THEOCHEM) (2002) 583(1-3): 199-213 Kivonat

• Side-chain conformational potential energy surfaces associated with all major backbone folds of neutral tautomers of N- and C-protected L-histidine

  Péter Hudáky , Tamás Beke , András Perczel

  J. Mol. Struct. (THEOCHEM) (2002) 583(1-3), 117-135 Kivonat

• Engineering new peptidic inhibitors from a natural chymotrypsin inhibitor

  Zoltán Mucsi , András Perczel , György Orosz

  J. Pept. Sci. (2002) 8(12): 643-655. Kivonat

• Toward direct determination of conformations of protein building units from multidimensional NMR experiments III-A theoretical case study of For-L-Phe-NH2.

  András Perczel , Attila G. Császár

  Eur. Phys. J. (2002) D20: 513-530.

2001

• Cryo-bioorganic chemistry: freezing effect on stereoselection of L- and DL-leucine cooligomerization in aqueous solution

  Tamás Vajda , Miklós Hollósi

  Cell. Mol. Life Sci. (2001) 58: 343-346 | 11289315 Kivonat

• Peptide models XXXI. Conformational properties of hydrophobic residues shaping the core of proteins. An ab initio study of N-formyl-l-valinamide and N-formyl-L-phenyalaninamide.

  Péter Hudáky , Imre Jákli , Attila G. Császár , András Perczel

  J. Comput. Chem. (2001) 22: 732-751. Kivonat

• α- and 3₁₀ -helix interconversion: A quantum-chemical study on polyalanine systems in the gas phase and in aqueous solvent.

  Igor A. Topol , Stanley K. Burt , Eugen Deretey , Ting-Hua Tang , András Perczel , Alexander Rashin , Imre G. Csizmadia

  J. Am. Chem. Soc. (2001) 123: 6054-6060. Kivonat

• Toward direct determination of conformations of protein building units from multidimensional NMR experiments part II: A theoretical case study of formyl-L-valine amide.

  András Perczel , Attila G. Császár

  Chem Eur J (2001) 7: 1069-1083. Kivonat

2000

• A new potent calmodulin antagonist with arylalkylamine structure: crystallographic, spectroscopic and functional studies

  Veronika Harmat , Zsolt Böcskei , Gábor Náray-Szabó , Imre Bata , Andrea S. Csutor , István Hermecz , Péter Arányi , Beáta Szabó , Károly Liliom , Beáta G. Vértessy

  J. Mol. Biol. (2000) 297(3):747-755. | DOI: 10.1006/jmbi.2000.3607 | PMID: 10731425 Kivonat

• Toward direct determination of conformations of protein building units from multidimensional NMR experiments I. A theoretical case study of For-Gly-NH2 and For-L-Ala-NH2.

  András Perczel , Attila G. Császár

  J. Comput. Chem. (2000) 21: 882-900. Kivonat

• Deciphering factors which determine the Ramachandran surface of Peptides. The aplication of isodesmic surfaces ΔE_ID(φ,ψ) to analyze the contribution of rotating moieties to the shape of potential energy surfaces.

  András Perczel , Péter Hudáky , Imre G. Csizmadia

  J. Mol. Struct. (THEOCHEM) (2000) 500: 59-96. Kivonat

1998

• Simultaneous binding of drugs with different chemical structures to Ca2+-calmodulin: crystallographic and spectroscopic studies

  Beáta G. Vértessy , Veronika Harmat , Gábor Náray-Szabó , Zsolt Böcskei , Ferenc Orosz , Judit Ovádi

  Biochemistry (1998) 37(44):15300-15310. | DOI: 10.1021/bi980795a | PMID: 9799490 Kivonat

1996

• Peptide models. 18. Hydroxymethyl side-chain induced backbone conformational shifts of For-l-Ser-NH2. All ab initio conformers of For-l-Ser-NH2.

  András Perczel , Ödön Farkas , Imre G. Csizmadia

  J. Am. Chem. Soc. (1996) 118: 7809-7817.

• Amino acid conformational analyses of proteins (ACAP program).

  Péter Hudáky , András Perczel , Imre G. Csizmadia

  J. Mol. Struct. (THEOCHEM) (1996) 362: 263-273. Kivonat

1995

• Searching for the simplest structural units to describe the 3-dimensional structure of proteins (Review).

  András Perczel , Imre G. Csizmadia

  Int..Rev. Phys. Chem. (1995) 14: 127-168.

1993

• Peptide models. 6. New beta-turn conformations from ab initio calculations confirmed by X-ray data of proteins.

  András Perczel , Michael A. McAllister , Pál Császár , Imre G. Csizmadia

  J. Am. Chem. Soc. (1993) 115: 4849-4858.

• Peptide models. 3. Conformational potential-energy hypersurface of formyl-L-valinamide.

  Wladia Viviani , Jean Louis Rivail , András Perczel , Imre G. Csizmadia

  J. Am. Chem. Soc. (1993) 115: 8321-8329.

1991

• Peptide models. 1. Topology of selected peptide conformational potential-energy surfaces (Glycine and alanine derivatives).

  András Perczel , János G. Ángyan , Márton Kajtár , Wladia Viviani , Jean Louis Rivail , John Frank Marcoccia , Imre G. Csizmadia

  J. Am. Chem. Soc. (1991) 113: 6256-6265.