Using both classical organic chemistry and modern bacterial expression systems we synthesize polypeptides, foldamers and proteins of various size and biological significance. Structure elucidation and internal dynamics of biomolecules are completed by X-ray and bioNMR spectroscopy, as well as molecular modeling, applied quantum chemistry and bioinformatics. We do cooperate with both Hungarian and foreign research teams on subjects ranging from organic chemistry to molecular biology. Recently we are synthesizing amino acids derived form carbohydrates, determining conformational properties of beta amino acids, synthesizing foldamers, expressing Exenatide-4 analogs used to treat type II Diabetes Mellitus, and conducting research for a better understanding Alzheimer’s and other conformational diseases, etc…Devoted students and people interested in modern structural chemistry and biology are always welcome.
Dániel Horváth , Nóra Taricska , Ernő Keszei , Pál Stráner , Viktor Farkas , Gábor K. Tóth , András Perczel
Compactness of Protein Folds Alters Disulfide‐Bond Reducibility by Three Orders of Magnitude: A Comprehensive Kinetic Case Study on the Reduction of Differently Sized Tryptophan Cage Model Proteins
ChemBioChem 21(5), 681-695 | doi.org/10.1002/cbic.201900470 (2020) Kivonat
Nóra Taricska , Dániel Horváth , Dóra K. Menyhárd , Hanna Ákontz-Kiss , Masahiro Noji , Masatomo So , Yuji Goto , Toshimichi Fujiwara , András Perczel
The route from the folded to the amyloid state: exploring the potential energy surface of a drug-like miniprotein
Chemistry A European Journal 26(9), 1968-1978 | doi.org/10.1002/chem.201903826 (2020) Kivonat
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