in spectra




in crystal

 X-ray diffraction,



in silico

bio-informatics, applied QM,

molecular modeling,...


in vivo/in vitro

biotechnology, protein production, 

preparative work, classical synthesis,..


Dsc 0059 1

We do cooperate with both Hungarian and foreign research teams on subjects ranging from organic chemistry to molecular biology. We run several ELTE-based, joint research projects, even at the national level, such as MedInProt, HunProtExc, or the SynthPlusz Excellence Programs. Recently we are synthesizing amino acids derived from carbohydrates, determining conformational properties of beta amino acids, synthesizing foldamers, expressing Exenatide-4 analogs used to treat type II Diabetes Mellitus, and conducting research for a better understanding Alzheimer’s and other conformational diseases. Furthermore, we work on the structure and dynamics of kRas signaling protein, which plays an important role in tumor diseases. Devoted students, postdocs and researchers interestedin modern structural chemistry and biology.


Csoport 1


  • Covalent fragment mapping of KRasG12C revealed novel chemotypes

    The G12C mutant KRas is considered druggable by covalent inhibitors. We have screened a covalent electrophilic fragment library (diverse non-covalent scaffolds with 40 different electrophilic functionalities) to identify suitable lead molecules targeting Cys12. The screening was based on Ellman's free thiol, protein NMR and cell viability assays. Two potential inhibitor chemotypes were identified.

    Our results are published in the European Journal of Medicinal Chemistry.

  • Succinct Amyloid and Nonamyloid Patterns in Hexapeptides

    Based on the "Budapest Amyloid Predictor" artificial intelligence program, we determined the most highly amyloidogenic patterns, e.g. CxFLWx, FxFLFx, xxIVIV hexapeptides, out of the 64 million, 6 residue long oligopeptides. A total of 5,531 such patterns are revealed!

    Our results can be read in ACS Publications:

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Recent Publications

  • Zoltán Orgován , Nikolett Péczka , László Petri , Péter Ábrányi-Balogh , Ivan Ranđelović , Szilárd Tóth , Gergely Szakács , Kinga Nyíri , Beáta Vértessy , Gyula Pálfy , István Vida , András Perczel , József Tóvári , György M. Keserű
    Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency
    European Journal of Medicinal Chemistry 250, 115212, ISSN 0223-5234 I DOI: 10.1016/j.ejmech.2023.115212. (2023) Kivonat
  • Anna J. Kiss-Szemán , Luca Takács , Zoltán Orgován , Pál Stráner , Imre Jákli , Gitta Schlosser , Simonas Masiulis , Veronika Harmat , Dóra K. Menyhárd , András Perczel
    A carbapenem antibiotic inhibiting a mammalian serine protease: structure of the acylaminoacyl peptidase–meropenem complex
    Chemical Science 13, 14264 - 14276 I DOI: 10.1039/D2SC05520A (2022) Kivonat
  • Ágnes Ábrahám , Flavio Massignan , Gergő Gyulai , Miklós Katona , Nóra Taricska , Éva Kiss
    Comparative Study of the Solid-Liquid Interfacial Adsorption of Proteins in Their Native and Amyloid Forms
    Int. J. Mol. Sci. 23(21), 13219 I DOI: 10.3390/ijms232113219 (2022) Kivonat
  • Zsolt Gulyás , Blanka Moncsek , Kamirán Áron Hamow , Pál Stráner , Zoltán Tolnai , Eszter Badics , Norbert Incze , Éva Darkó , Valéria Nagy , András Perczel , László Kovács , Vilmos Soós
    D27-LIKE1 isomerase has a preference towards trans/cis and cis/cis conversions of carotenoids in Arabidopsis
    The Plant Journal DOI: 10.1111/tpj.16017 (2022) Kivonat
  • Kende Attila Béres , Zoltán Homonnay , Berta Barta Holló , Maria Gracheva , Vladimir M. Petruševski , Attila Farkas , Zsolt Dürvanger , László Kótai
    Synthesis, structure, and Mössbauer spectroscopic studies on the heat‑induced solid‑phase redox reactions of hexakis(urea‑O)iron(III) peroxodisulfate
    Journal of Materials Research DOI: 10.1557/s43578-022-00794-w (2022) Kivonat
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