We do cooperate with both Hungarian and foreign research teams on subjects ranging from organic chemistry to molecular biology. We run several ELTE-based, joint research projects, even at the national level, such as MedInProt, HunProtExc, or the SynthPlusz Excellence Programs. Recently we are synthesizing amino acids derived from carbohydrates, determining conformational properties of beta amino acids, synthesizing foldamers, expressing Exenatide-4 analogs used to treat type II Diabetes Mellitus, and conducting research for a better understanding Alzheimer’s and other conformational diseases. Furthermore, we work on the structure and dynamics of kRas signaling protein, which plays an important role in tumor diseases. Devoted students, postdocs and researchers interestedin modern structural chemistry and biology.
News
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Design and Characterization of a Multistage Peptide-Based Vaccine Platform to Target Mycobacterium tuberculosis Infection
In our recent collaborative article, we described the design and development of an immunogenic, self-adjuvanting, multistage vaccine platform against Mycobacterium tuberculosis (Mtb), obtained by combining the synthesis of a multiepitope lipopeptide with chemoselective ligation.
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Amide isomerization pathways: Electronic and structural background of protonation- and deprotonation-mediated cis-trans interconversions
In this article a possible reaction route for the cis-trans isomerization of non-proline (Xxx-nonPro) peptide bonds is described via protonation using DFT and coupled cluster computational results.
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Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency
We report a covalent fragment screening of our electrophilic fragment library of diverse non-covalent scaffolds to identify fragments as suitable starting points targeting the Cys12 position of the oncogenic protein KRasG12C.
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Recent Publications
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Ádám A. Kelemen , András Perczel , Dániel Horváth , Imre Jákli
Amide isomerization pathways: Electronic and structural background of protonation- and deprotonation-mediated cis-trans interconversions
J. Chem. Phys. 159 (15): 154301. | DOI: https://doi.org/10.1063/5.0165772 (2023) Kivonat -
Chiara Bellini , Emil Vergara , Fruzsina Bencs , Kinga Fodor , Szilvia Bõsze , Denis Krivić , Bernadett Bacsa , Sára Eszter Surguta , József Tóvári , Rajko Reljic , Kata Horváti
Design and Characterization of a Multistage Peptide-Based Vaccine Platform to Target Mycobacterium tuberculosis Infection
Bioconjugate Chemistry 34(10): 1738–1753 (2023) Kivonat -
Dániel Horváth , Zsolt Dürvanger , Dóra K. Menyhárd , Máté Sulyok-Eiler , Fruzsina Bencs , Gergő Gyulai , Péter Horváth , Nóra Taricska , András Perczel
Polymorphic amyloid nanostructures of hormone peptides involved in glucose homeostasis display reversible amyloid formation
Nature Communications 14, 4621 I https://doi.org/10.1038/s41467-023-40294-x (2023) Kivonat -
Márton Gadanecz , Zsolt Fazekas , Gyula Pálfy , Dóra Karancsiné Menyhárd , András Perczel
NMR-Chemical-Shift-Driven Protocol Reveals the Cofactor-Bound, Complete Structure of Dynamic Intermediates of the Catalytic Cycle of Oncogenic KRAS G12C Protein and the Significance of the Mg2+ Ion
Int. J. Mol. Sci. 24(15), 12101 I https://doi.org/10.3390/ijms241512101 (2023) Kivonat -
Dóra Nagy-Fazekas , Zsolt Fazekas , Nóra Taricska , Pál Stráner , Dóra Karancsiné Menyhárd , András Perczel
Inhibitor Design Strategy for Myostatin: Dynamics and Interaction Networks Define the Affinity and Release Mechanisms of the Inhibited Complexes
Molecules 28(15), 5655 | https://doi.org/10.3390/molecules28155655 (2023) Kivonat - More publications