Using both classical organic chemistry and modern bacterial expression systems we synthesize polypeptides, foldamers and proteins of various size and biological significance. Structure elucidation and internal dynamics of biomolecules are completed by X-ray and bioNMR spectroscopy, as well as molecular modeling, applied quantum chemistry and bioinformatics. We do cooperate with both Hungarian and foreign research teams on subjects ranging from organic chemistry to molecular biology. Recently we are synthesizing amino acids derived form carbohydrates, determining conformational properties of beta amino acids, synthesizing foldamers, expressing Exenatide-4 analogs used to treat type II Diabetes Mellitus, and conducting research for a better understanding Alzheimer’s and other conformational diseases, etc…Devoted students and people interested in modern structural chemistry and biology are always welcome. 
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Recent Publications
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Gyula Pálfy , Dóra K. Menyhárd , András Perczel
Dynamically encoded reactivity of Ras enzymes: opening new frontiers for drug discovery
Cancer and Metastasis Reviews doi.org/10.1007/s10555-020-09917-3 (2020) Kivonat -
Dóra K. Menyhárd , Gyula Pálfy , Zoltán Orgován , István Vida , György M. Keserű , András Perczel
Structural impact of GTP binding on downstream KRAS signaling
Chemical Science DOI: 10.1039/d0sc03441j (2020) Kivonat -
Nikoletta Murvai , Lajos Kalmár , Bianka Szalainé Ágoston , Beáta Szabó , Ágnes Tantos , György Csikós , András Micsonai , József Kardos , Didier Vertommen , Phuong N. Nguyen , Nevena Hristozova , András Láng , Dénes Kovács , László Buday , Kyou-Hoon Han , András Perczel , Péter Tompa
Interplay of Structural Disorder and Short Binding Elements in the Cellular Chaperone Function of Plant Dehydrin ERD14
Cells 9(8), 1856 | doi: 10.3390/cells9081856 (2020) Kivonat -
Erika F. Dudás , Gyula Pálfy , Dóra K. Menyhárd , Fanni Sebák , Péter Ecsédi , László Nyitray , Andrea Bodor
Tumor‐Suppressor p53TAD1–60 Forms a Fuzzy Complex with Metastasis‐Associated S100A4: Structural Insights and Dynamics by an NMR/MD Approach
ChemBioChem 21 | doi.org/10.1002/cbic.202000348 (2020) Kivonat -
Péter Ecsédi , Gergő Gógl , Henrietta Hóf , Bence Kiss , Veronika Harmat , László Nyitray
Structure Determination of the Transactivation Domain of p53 in Complex with S100A4 Using Annexin A2 as a Crystallization Chaperone
Structure 28(8), 943-953.e4 | doi: 10.1016/j.str.2020.05.001 (2020) Kivonat - More publications