in spectra




in crystal

 X-ray diffraction,



in silico

bio-informatics, applied QM,

molecular modeling,...


in vivo/in vitro

biotechnology, protein production, 

preparative work, classical synthesis,..


Dsc 0059 1

We do cooperate with both Hungarian and foreign research teams on subjects ranging from organic chemistry to molecular biology. We run several ELTE-based, joint research projects, even at the national level, such as MedInProt, HunProtExc, or the SynthPlusz Excellence Programs. Recently we are synthesizing amino acids derived from carbohydrates, determining conformational properties of beta amino acids, synthesizing foldamers, expressing Exenatide-4 analogs used to treat type II Diabetes Mellitus, and conducting research for a better understanding Alzheimer’s and other conformational diseases. Furthermore, we work on the structure and dynamics of kRas signaling protein, which plays an important role in tumor diseases. Devoted students, postdocs and researchers interestedin modern structural chemistry and biology.


Csoport 1


  • Succinct Amyloid and Nonamyloid Patterns in Hexapeptides

    Based on the "Budapest Amyloid Predictor" artificial intelligence program, we determined the most highly amyloidogenic patterns, e.g. CxFLWx, FxFLFx, xxIVIV hexapeptides, out of the 64 million, 6 residue long oligopeptides. A total of 5,531 such patterns are revealed!

    Our results can be read in ACS Publications:

  • The Importance of Mg2+-Free State in Nucleotide Exchange of Oncogenic K-Ras Mutants

    NMR relaxation data and MD simulations were combined to decipher the role of slow dynamics in the wild-type and 3 oncogenic P-loop mutants of K-Ras: a 2-state conformational exchange (ms timescale) model was established for both the GDP and GTP-bound forms of K-Ras.

    Our results can be read in the journal Chemistry Europe:

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