Using both classical organic chemistry and modern bacterial expression systems we synthesize polypeptides, foldamers and proteins of various size and biological significance. Structure elucidation and internal dynamics of biomolecules are completed by X-ray and bioNMR spectroscopy, as well as molecular modeling, applied quantum chemistry and bioinformatics. We do cooperate with both Hungarian and foreign research teams on subjects ranging from organic chemistry to molecular biology. Recently we are synthesizing amino acids derived form carbohydrates, determining conformational properties of beta amino acids, synthesizing foldamers, expressing Exenatide-4 analogs used to treat type II Diabetes Mellitus, and conducting research for a better understanding Alzheimer’s and other conformational diseases, etc…Devoted students and people interested in modern structural chemistry and biology are always welcome. 
News
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Approaches to Pyranuronic β-Sugar Amino Acid Building Blocks of Peptidosaccharide Foldamers
Pyranuronic β-sugar amino acids (β-SAAs) are biocompatible and tuneable building blocks of foldamers and α/β chimera peptides. The scalable and economical total synthesis of two building blocks was described. These C-4 epimers, Fmoc-GlcAPU(Me)-OH and Fmoc-GalAPU(Me)-OH, which are suitable for solid phase peptide synthesis, were prepared via a common oxime intermediate. The new synthesis uses nine consecutive steps, starting from methyl α-D-glucopyranoside. The synthesis is fine-tuned, optimized, and ready for largescale and cost-efficient production.
Eur. J. Org. Chem. 2018, 355
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New building blocks synthesized: just published in Amino Acids
„C-3 epimers of sugar amino acids as foldameric building blocks: improved synthesis, useful derivatives, coupling strategies”. Yield optimized, scalable and environment-friendly protocols for making β-sugar amino acids and their derivatives to built up α/β-chimera peptides.
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Recent Publications
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Pál Stráner , Eszter Balogh , Gusztáv Schay , Christelle Arrondel , Ágnes Mikó , Gerda L'Auné , Alexandre Benmerah , András Perczel , Dóra K. Menyhárd , Corinne Antignac , Géraldine Mollet , Kálmán Tory
C-terminal oligomerization of podocin mediates interallelic interactions
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease S0925-4439(18)30132-30137 | DOI: 10.1016/j.bbadis.2018.04.008 | PMID: 29660491 (2018) Kivonat -
Tibor Pasinszki , Dániel Dzsotján , Győző György Lajgut , Veronika Harmat , Antal Csámpai , Andrea Bor , István Zupkó
Synthesis, spectral- and theoretical study, x-ray analysis, and antiproliferative activity of 4,5-dihydrobenzoferroceno[1,2-d][1,2,3]selenadiazole and its benzo-fused analogue
Journal of Organometallic Chemistry 863:70-76. | DOI: 10.1016/j.jorganchem.2018.03.031 (2018) Kivonat -
Sabine Schuster , Beáta Biri-Kovács , Bálint Szeder , Viktor Farkas , László Buday , Zsuzsanna Szabó , Gábor Halmos , Gábor Mező
Synthesis and in vitro biochemical evaluation of oxime bond-linked daunorubicin–GnRH-III conjugates developed for targeted drug delivery
Beilstein J. Org. Chem. Beilstein J. Org. Chem. 14:756–771 | DOI:10.3762/bjoc.14.64 (2018) Kivonat -
Anna Huber , Dorottya Hajdu , Doris Bratschun-Khan , Zoltán Gáspári , Mihayl Varbanov , Stéphanie Philippot , Ádám Fizil , András Czajlik , Zoltán Kele , Christoph Sonderegger , László Galgóczy , Andrea Bodor , Florentine Marx , Gyula Batta
New Antimicrobial Potential and Structural Properties of PAFB: A Cationic, Cysteine-Rich Protein from Penicillium chrysogenum Q176
Scientific Reports 8:1751. PMID: 29379111 | DOI:10.1038/s41598-018-20002-2 (2018) Kivonat -
Viktória Goldschmidt Gőz , István Pintér , Veronika Harmat , András Perczel
Approaches to Pyranuronic beta-Sugar Amino Acid Building Blocks of Peptidosaccharide Foldamers
Eur. J. Org. Chem. 355-361. DOI: 10.1002/ejoc.201701612 (2018) Kivonat - More publications