The Hun-Ren-ELTE Molecular Modelling Research Group and the Structural Chemistry and Biology Laboratory are located at the Institute of Chemistry, Faculty of Natural Sciences, Eötvös Loránd University. We collaborate with many national and international structural research groups in various fields of organic- and peptide-chemistry, molecular biology and biochemistry to better understand the wonderful but hidden world of the microcosm. We operate and develop a synthetic platform including a system for the synthesis of polypeptides and protein domains based on flow chemistry, and a fermentor reactor for the production of partially unlabelled and partially 15N-and 13C-isotopically labelled proteins.
Our topics include spatially oriented projects such as foldamer research, understanding self-assembled and reversible amyloid formation, total synthesis of non-natural amino acids and sugar amino acids and chemical synthesis of polypeptides and protein domains. We also have projects to produce drugs and molecules as potential lead compounds related to diseases. These include a deeper understanding of the molecular basis of Alzheimer's disease, the kRas signalling protein that plays an important role in tumour diseases, the mechanism of antibiotics and a deeper understanding of certain drug-drug interactions. Our protein modelling work has also successfully addressed bioinformatics, molecular modelling, drug design and applied quantum chemistry challenges. Over the last decade, we have led several ELTE-centred collaborations and tenders to exploit the potential of important high-resolution structural tools such as NMR spectroscopy, X-ray crystallography and cryo-electron microscopy at the highest level and efficiently, to share our knowledge with others and to collaborate with industrial partners. (MedInProt, HunProtExc, or the Level Plus Programmes of Excellence, iNEXT-Discovery H-2020, etc.) Our open-minded, enthusiastic team welcomes students and is happy to cooperate with all interested researchers.
News
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Doctoral title
On June 20, Dóra Nagy-Fazekas obtained her doctorate with summa cum laude within the Synthetic Chemistry, Organic and Biomolecular Chemistry program of the ELTE György Hevesy Doctoral School of Chemistry! Congratulation!
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Kálmán Medzihradszky Lecturer Award
We are proud that a large number of our colleagues successfully participated in the MTA Peptide Chemistry and NMR Working Committee Meetings, and the MKE KeMoMo-QSAR event in May 2024. Special congratulations to our PhD student Kristóf Ferentzi for being awarded the Kálmán Medzihradszky Lecturer Award by the jury this year.
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Highlighting Organic Chemistry in Hungary
The "Highlighting Organic Chemistry in Hungary" event organised by the European Chemical Society gave seven Hungarian research teams the opportunity to be in the spotlight. We are proud and honoured to be among the 7 selected research groups and to have had this opportunity. The recorded presentations can be accessed here (https://youtu.be/QUdajUBbjk0), where after the short introduction some of our current research topics are summarised between 12 and 43 minutes.
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Recent Publications
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Ho-Jin Lee , Shi-Wei Liu , Máté Sulyok-Eiler , Veronika Harmat , Viktor Farkas , Zoltán Bánóczi , Mouna El Khabchi , Hua-Jun Shawn Fan , Kimihiko Hirao , Jong-Won Song
Neighbor effect on conformational spaces of alanine residue in azapeptides
Heliyon 10(12), e33159 (2024) Kivonat -
Zsolt Fazekas , Dóra K. Menyhárd , András Perczel
LoCoHD: a metric for comparing local environments of proteins
Nature Communications 15, 4029 I DOI: https://doi.org/10.1038/s41467-024-48225-0 (2024) Kivonat -
Szebasztián Szaniszló , Antal Csámpai , Dániel Horváth , Richárd Tomecz , Viktor Farkas , András Perczel
Unveiling the Oxazolidine Character of Pseudoproline Derivatives by Automated Flow Peptide Chemistry
International Journal of Molecular Sciences 25(8), 4150 (2024) Kivonat -
Karima Tarchoun , Dóra Soltész , Viktor Farkas , Ho-Jin Lee , Ildikó Szabó , Zoltán Bánóczi
Influence of Aza-Glycine Substitution on the Internalization of Penetratin
Pharmaceutics 16(4), 477 (2024) Kivonat -
Kristóf Ferentzi , Dóra Nagy-Fazekas , Viktor Farkas , András Perczel
Synthesis of small protein domains by automated flow chemistry
Reaction Chemistry & Engineering 9, 58-69 (2024) Kivonat - More publications