Using both classical organic chemistry and modern bacterial expression systems we synthesize polypeptides, foldamers and proteins of various size and biological significance. Structure elucidation and internal dynamics of biomolecules are completed by X-ray and bioNMR spectroscopy, as well as molecular modeling, applied quantum chemistry and bioinformatics. We do cooperate with both Hungarian and foreign research teams on subjects ranging from organic chemistry to molecular biology. Recently we are synthesizing amino acids derived form carbohydrates, determining conformational properties of beta amino acids, synthesizing foldamers, expressing Exenatide-4 analogs used to treat type II Diabetes Mellitus, and conducting research for a better understanding Alzheimer’s and other conformational diseases, etc…Devoted students and people interested in modern structural chemistry and biology are always welcome.
Nikoletta Murvai , Lajos Kalmár , Bianka Szalainé Ágoston , Beáta Szabó , Ágnes Tantos , György Csikós , András Micsonai , József Kardos , Didier Vertommen , Phuong N. Nguyen , Nevena Hristozova , András Láng , Dénes Kovács , László Buday , Kyou-Hoon Han , András Perczel , Péter Tompa
Interplay of Structural Disorder and Short Binding Elements in the Cellular Chaperone Function of Plant Dehydrin ERD14
Cells 9(8), 1856 | doi: 10.3390/cells9081856 (2020) Kivonat
Erika F. Dudás , Gyula Pálfy , Dóra K. Menyhárd , Fanni Sebák , Péter Ecsédi , László Nyitray , Andrea Bodor
Tumor‐Suppressor p53TAD1–60 Forms a Fuzzy Complex with Metastasis‐Associated S100A4: Structural Insights and Dynamics by an NMR/MD Approach
ChemBioChem 21 | doi.org/10.1002/cbic.202000348 (2020) Kivonat
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