Published January 20, 2025 10:52
Source https://doi.org/10.1021/acs.joc.4c01589
Cyclodextrins, particularly OH-free β-CyD, significantly reduce peptide aggregation during SPPS, enhancing the synthesis of challenging peptides like amyloid β (1-42). This innovative approach improves crude peptide purity by 8%-19%, offering an alternative to traditional pseudoproline monomer methods.
