Dr. András Perczel D.Sc., Corresponding member of HAS, full professor
Address: 1518 Budapest 112, Pf.: 32, Hungary
Room: 427/A
Email:
Phone: +36 (1) 372-2500 / 1653
Fax: +36 (1) 372-2620
Born At: May 10, 1959
Studies
- 1973-1977: Roman Catholic High-school of Piarists
- 1980-1981: Technical University (Veszprém/Hungary)
- 1982-1985: Eötvös Loránd University (Budapest / Hungary) M.Sc. Chemistry major (1136/1985)
- 1989: Ph.D. "Synthesis and conformational analysis of peptides and glycopeptides” (ELTE/Budapest; ELTE D-285/1988)
- 1993: C.Sd. „Synthesis and conformational analysis of peptides and peptide derivatives via synthetic, computational and spectroscopic methods” (HAS-14337)
- 1998: D.Sc. "Modelling secondary structural elements of proteins via synthetic, spectroscopic and computational methods" (HAS-3660)
- 1999: Habilitation (ELTE 210/1999)
- 2010: Member of the Hungarian Academy of Sciences
- 2012: Member of The Academy of Europe
Posts Held
- 2007- 2010 Head of the Department of Organic Chemistry, Inst. Of Chemistry, ELTE
- 2001- Professor at the Dep. of Chemistry, Inst. Of Chemistry, ELTE
- 1998-2001: Research Professor at the Dep. of Chem., Inst. Of Chemistry, ELTE
- 1997-1998: Research associate prof. at the Dep. of Chem., Inst. Of Chemistry, ELTE
- 1995-1997: Research fellow, Dep. of Biochemistry, Oxford Univ., UK
- 1993-1995: Research associate at the Dep. of Chem., Inst. Of Chemistry, ELTE
- 1992-1994: NSERC. Post doc. Fellow at the Dep. of Chem., Univ. of Toronto, Canada
- 1989-1992: Post. Doc. Fellow at the Dep. of Biochemistry, Brandeis Univ., Massachusetts USA
- 1985-1988: Fellow of the Hungarian Academy of Sciences (PhD student)
Actual courses
- 2012-13/II Organic chemistry for biologists (lectures: kv1c1bk1) 14*4 h (Monday/0.65 14.00-16.00, Wednesday/0.65 12.00-14.00)
- 2012-13/II Biological chemistry (lectures: kb1n1202) 14*3 h (Thursday/-1.75 8.00-11.00)
- 2012-13/II Structure and Dynamics of Proteins and peptides via spectroscopic methods (special courses: kv2n9o35) 14*2 h
Teaching experiences
organic chemistry courses and practicals, special courses in bio-spectroscopy
various graduate, post-graduate lecture courses in structural chem.
supervision of two dozens of graduate and D.Phil. students
details:
- 2011- BioNMR spectroscopy (special course and practicals) 14*(2+3) h./semester I
- 2009- Biological chemistry (lectures) 14*4 h./semester II
- 2003-08 Theoretical organic chemistry (lectures) 14*2 h./semester I
- 2008- Natural products (lectures biology major) 14*3 h./semester I for
- 2001- Organic chemistry (lectures for biology major) 14*4 h./semester II
- 1997- NMR pulse sequences in structure determination (special course) 14*2h./semester I
- 1994- Structural investigation of peptides and proteins (special course) 14*2h./semester II
- 1985-88, 1993-95, 1996-2001 Organic chemistry (laboratory course) 14*6 h./semester
Students
Research
- Synthesis of peptides on solid phase and using biotechnology
- Spectroscopic analysis (CD, NMR) of bioactive peptides
- Structure and stability of α- and β-peptides, foldamers and their nanofibril-formation and aggregation properties
- BioNMR of protein : structure, dynamics and function of globular and disordered (IDP) systems
- Mapping protein-ligand interactions, structural investigations of biologically important systems (enzymes, receptors, etc.)
Research experiences
- Prof. R.Daudel (Pierre et Marie Curie, Sorbon, Paris, France 1989)
- Prof. G.D.Fasman (Brandeis, Boston, USA 1989-1992)
- Prof. H.H.Mantsch (NRC Ottawa, Canada 1991)
- Prof. I.G.Csizmadia (Univ. of Toronto, Canada 1991, 1992-1994)
- Prof. I.D.Campbell (Univ. of Oxford, UK 1994, 1995-1997, 1998) FEBS researcher
- Prof. J. Markley (Univ. Of Madison, USA, 2006), Fulbright fellow
Publications
Publications: Over 260 peer reviewed articles, over 5000 citations of non-collaborating authors,
with a cumulative IF of >700; H-index=45
Grants: Hungarian Research Foundation OTKA (10), Grant form the Hungarian Ministry of Education and Culture (4), Welcome Foundation Grant (2), ICGEB-UNESCO (2), East-NMR (FP7), COST(1)
Prime Publications
-
Orsolya Barabás , Vince Grolmusz , Zoltán Szabadka , Imre Zagyva , Zoltán Kele , Edina Rosta , András Perczel , Andrea Bodor , Veronika Németh , Matthias Wilmanns
Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, <sup>31</sup>P-NMR spectroscopy and reaction path modelling
Nucleic Acids Res. DOI: 10.1093/nar/gkt756 | PMID: 23982515 (2013) Kivonat -
Adriana D. Garro , Ana M. Rodríguez , Javier López Cascales , Botond Penke , Csaba Somlai , András Perczel , Gabriela Feresin , Alejandro Tapia , Beatriz Lima , José A. Bombasaro , Mónica S. Olivella , Ricardo D. Enriz
Penetratin and derivatives acting as antibacterial agents
Chem. Biol. Drug. Des. 82(2):167-177. | DOI: 10.1111/cbdd.12143 | PMID: 23581817 (2013) Kivonat -
Gábor Pohl , Esther Gorrea , Vicenç Branchadell , Rosa M. Ortuño , András Perczel , György Tarczay
Foldamers of β-peptides: conformational preference of peptides formed by rigid building blocks. The first MI-IR spectra of a triamide nanosystem.
Amino Acids 45(4):957-973. | DOI: 10.1007/s00726-013-1552-7 | PMID: 23860847 (2013) Kivonat -
Imre Jákli , Szilárd N. Fejér , Ödön Farkas , Béla Viskolcz , Svend J. Knak Jensen , Imre G. Csizmadia , András Perczel
Helix compactness and stability: Electron structure calculations of conformer
Chem. Phys. Lett. 563:80-87. (2013) Kivonat -
Petra Rovó , Pál Stráner , András Láng , István Bartha , Kristóf Huszár , László Nyitray , András Perczel
Structural insights into the Trp-cage folding intermediate formation
Chem. Eur. J. 19(8):2628-2640. | DOI: 10.1002/chem.201203764 | PMID: 23319425 (2013) Kivonat
Awards
- Széchenyi Prize, 2021
- Scientist of the year, Pest County, 2012
- Elected member of Science Europea , 2012
- Bolyai Prize, perhaps the highest scientific award in Hungary, 2011
- Elected member of the Hungarian Academy of Sciences , 2010
- Fulbright fellow, 2006
- Scientist of the year, Sanofi-Synthelabo, 2004
- Széchényi Professor (1998-2002)
- Scientific award (1st price), 1997 (form the Faculty of Science L. Eötvös. Univ.)
- Zemplén Géza junior award, 1996 ( form the Hungarian Acad. of Sci.)
- Pro Scientia gold medal, 1993 and 1995 (form HAS)