Published May 23, 2023 16:15
Interaction of calmodulin and melittin is widely used as a test system for method development, and as a reference in studies of calmodulin interactions. However, results on the interaction pattern of this complex were non-conclusive so far. Our aim was to explore the fine details of this interaction. Our crystallographic study revealed multiple different binding modes, and our succeeding MD simulations concluded that these could transform to each other: the nanomolar affinity binding of this complex is realized by a ‘slippery’ binding way and interchanging interactions.
Our publication has been selected as one of "Editors' Picks," of the Journal of Biological Chemistry.