Anna J. Kiss-Szemán, PhD tudományos munkatárs

Address: 1117 Budapest, Pázmány Péter str. 1/A, Hungary

Room: 5.123

Email:

Phone: +36 (1) 372-2500 / 6547

Born At: January 09, 1989

Born In: Budapest

Facility Manager: Dr. Veronika Harmat

Lab: Protein crystallography lab.

Studies

2009-2012 Eötvös Loránd University - Bachelor of Science, Chemistry (BSc), Budapest, Hungary

2012-2014 Eötvös Loránd University - Master of Science, Chemist (MSc), Budapest, Hungary

2014 - 2018 Eötvös Loránd University - Chemistry Doctoral School (PhD) - Synthetic Chemistry, Materials Science and Biomolecular Chemistry, Budapest, Hungary

Posts Held

MTA public body member

Research

Protein structure research - macromolecular X-ray crystallography (2010- ), 

cryo-electronmicroscopy (2019-)

Protein isolation and expression (2013- )

Human disease-causing protein structure determination

Publications

Dóra K. Menyhárd, Anna Kiss-Szemán, Éva Tichy-Rács, Balázs Hornung, Krisztina Rádi, Zoltán Szeltner, Klarissza Domokos, Ilona Szamosi, Gábor Náray-Szabó, László Polgár and Veronika Harmat
A Self-compartmentalizing Hexamer Serine Protease from Pyrococcus Horikoshii: SUBSTRATE SELECTION ACHIEVED THROUGH MULTIMERIZATION J. Biol. Chem. (2013) 288: 17884-17894.

Harmat, V ; Kocsis, A ; Kiss-Szeman, A ; Pal, G ; Zavodszky, P ; Gal, P
Autoactivation of MASP-2: Role of exosite interactions
MOLECULAR IMMUNOLOGY 47 : 13 pp. 2256-2257. , 2 p. (2010)

Kiss-Szeman, Anna ; Harmat, Veronika ; Menyhard, Dora K
Solving the structure of a mammalian acylaminoacyl-peptidase
ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES 72 : S pp. S211-S212. Paper: MS6-P1 (2016)

Kiss-Szemán, Anna J. ; Harmat, Veronika ; Menyhárd, Dóra K.
Achieving Functionality Through Modular Build-Up: Structure and Size Selection of Serine Oligopeptidases
CURRENT PROTEIN AND PEPTIDE SCIENCE 20 : 11 pp. 1089-1101. , 13 p. (2019)

Kiss-Szeman, Anna
COMPETITIVE BINDING OF POTENTIAL DRUG MOLECULES AT THE ACTIVE SITE OF AN ACYLPEPTIDE-HYDROLASE
ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES 75 pp. E129-E129. , 1 p. (2019)

Kiss-Szemán, Anna J. ; Stráner, Pál ; Jákli, Imre ; Hosogi, Naoki ; Harmat, Veronika ; Menyhárd, Dóra K. ; Perczel, András
Cryo-EM structure of acylpeptide hydrolase reveals substrate selection by multimerization and a multi-state serine-protease triad
CHEMICAL SCIENCE 13 : 24 pp. 7132-7142. , 11 p. (2022)

Kiss-Szemán, Anna J. ; Takács, Luca ; Orgován, Zoltán ; Stráner, Pál ; Jákli, Imre ; Schlosser, Gitta ; Masiulis, Simonas ; Harmat, Veronika ; Menyhárd, Dóra K. ; Perczel, András
A carbapenem antibiotic inhibiting a mammalian serine protease: structure of the acylaminoacyl peptidase–meropenem complex
CHEMICAL SCIENCE 13 : 48 pp. 14264-14276. , 13 p. (2022)

Awards

3rd place on the XXXIst National Conference of Scientific Students' Associations (OTDK, Eger)

Medzihradszky Kálmán award (2022)

Publication award ELTE Institute of Chemistry (2023)

Kisfaludy award (2023)

Kajtár award (2023)