Anna J. Kiss-Szemán tudományos munkatárs

Address: 1117 Budapest, Pázmány Péter str. 1/A, Hungary

Room: 5.123

Email:

Phone: +36 (1) 372-2500 / 6547

Born At: January 09, 1989

Born In: Budapest

Facility Manager: Dr. Veronika Harmat

Lab: Protein crystallography lab.

Studies

2009-2012 Eötvös Loránd University - Bachelor of Science, Chemistry (BSc), Budapest, Hungary

2012-2014 Eötvös Loránd University - Master of Science, Chemist (MSc), Budapest, Hungary

2014 - 2018 Eötvös Loránd University - Chemistry Doctoral School (PhD) - Synthetic Chemistry, Materials Science and Biomolecular Chemistry, Budapest, Hungary

Research

Protein structure research - macromolecular X-ray crystallography (2010- ), cryo-electronmicroscopy (2019-
Protein isolation and expression (2013- )

Publications

Dóra K. Menyhárd, Anna Kiss-Szemán, Éva Tichy-Rács, Balázs Hornung, Krisztina Rádi, Zoltán Szeltner, Klarissza Domokos, Ilona Szamosi, Gábor Náray-Szabó, László Polgár and Veronika Harmat
A Self-compartmentalizing Hexamer Serine Protease from Pyrococcus Horikoshii: SUBSTRATE SELECTION ACHIEVED THROUGH MULTIMERIZATION J. Biol. Chem. (2013) 288: 17884-17894.

Harmat, V ; Kocsis, A ; Kiss-Szeman, A ; Pal, G ; Zavodszky, P ; Gal, P
Autoactivation of MASP-2: Role of exosite interactions
MOLECULAR IMMUNOLOGY 47 : 13 pp. 2256-2257. , 2 p. (2010)

Kiss-Szeman, Anna ; Harmat, Veronika ; Menyhard, Dora K
Solving the structure of a mammalian acylaminoacyl-peptidase
ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES 72 : S pp. S211-S212. Paper: MS6-P1 (2016)

Kiss-Szemán, Anna J. ; Harmat, Veronika ; Menyhárd, Dóra K.
Achieving Functionality Through Modular Build-Up: Structure and Size Selection of Serine Oligopeptidases
CURRENT PROTEIN AND PEPTIDE SCIENCE 20 : 11 pp. 1089-1101. , 13 p. (2019)

Kiss-Szeman, Anna
COMPETITIVE BINDING OF POTENTIAL DRUG MOLECULES AT THE ACTIVE SITE OF AN ACYLPEPTIDE-HYDROLASE
ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES 75 pp. E129-E129. , 1 p. (2019)

Kiss-Szemán, Anna J. ; Stráner, Pál ; Jákli, Imre ; Hosogi, Naoki ; Harmat, Veronika ; Menyhárd, Dóra K. ; Perczel, András
Cryo-EM structure of acylpeptide hydrolase reveals substrate selection by multimerization and a multi-state serine-protease triad
CHEMICAL SCIENCE 13 : 24 pp. 7132-7142. , 11 p. (2022)

Kiss-Szemán, Anna J. ; Takács, Luca ; Orgován, Zoltán ; Stráner, Pál ; Jákli, Imre ; Schlosser, Gitta ; Masiulis, Simonas ; Harmat, Veronika ; Menyhárd, Dóra K. ; Perczel, András
A carbapenem antibiotic inhibiting a mammalian serine protease: structure of the acylaminoacyl peptidase–meropenem complex
CHEMICAL SCIENCE 13 : 48 pp. 14264-14276. , 13 p. (2022)

Awards

3rd place on the XXXIst National Conference of Scientific Students' Associations (OTDK, Eger)

Medzihradszky Kálmán award (2022)