Published December 12, 2025 12:55
Published in Chemistry – A European Journal (DOI: 10.1002/chem.202502335), the study presents a sustainable peptide synthesis method combining flow chemistry with machine-learning optimization. Using an Anisole/DMSO (17:3) solvent system, racemization and aspartimide formation were minimized, enabling efficient peptide production in 12 minutes per cycle, setting a new benchmark for green and high-speed peptide synthesis.