Dr. Veronika Harmat Ph.D., assistant professor
Address: H-1117 Budapest, Pázmány Péter sétány 1/A
Room: 5.123
Email:
Phone: +36 (1) 372-2500 / 6547
Fax: +36 (1) 372-2592
Born At: April 24, 1973
Born In: Budapest
Studies
- 2003, Ph.D. in Structural Chemistry, Eötvös Loránd University
- 1996, M.Sc. in Chemistry Eötvös Loránd University
Posts Held
- 2014-2019 HAS, BRC, research fellow
- 2008- assistant professor, Eötvös Loránd University
- 2007- research fellow, Protein Modeling Group, HAS/ELTE
- 2003-2006 junior research fellow, Protein Modeling Group, HAS/ELTE
- 2001-2002 demonstrator, Eötvös Loránd University
Actual courses
- X-ray crystallography lectures (Chemistry M.Sc.)
- X-ray crystallography laboratory courses (Chemistry M.Sc.)
- Protein crystallography lectures (Chemistry and Structural Biology Ph.D., Biotechnology M.Sc.)
- Structural methods (Chemistry BSc, part of the course)
- Biocrystallography, Bioanalytics (X-ray crystallography, Biotechnology M.Sc.)
- Inorganic chemistry calculations practice (Chemistry B.Sc.)
- General chemistry laboratory courses (Chemistry and Biology B.Sc.)
Teaching experiences
- 2011- Methods in protein crytallography, Ph.D. course
- 2006-, 2019- Protein crystallography, special course in Chemistry, Biology and Biotechnology M.Sc.
- 1999- X-ray crystallography, semi-optional course in Chemistry
- 2000- X-ray crystallography laboratory course
- 2001-2002, 2008- General chemistry laboratory course (in Chemistry and Biology B.Sc.)
- 2008- General chemistry and Inorganic chemistry calculations courses (in Chemistry B.Sc.);
- 2009-2018 Inorganic chemistry laboratorycourse (in Earth Sciences B.Sc.)
Students
Research
Interest: Structural aspects of molecular recognition in protein action
- Structure-function relationships of DJ-1 (Cooperation: RCNS Institute of Organic Chemistry, Research Group for Neurodegenerative Disease Drug Discovery)
- Serin proteases of the complement system (specificity, autocatalytic activity, regulation) (Cooperation: RCNS Institute of Enzymology, Structural Biophysics group; ELTE Department of Biochemistry)
- Acylpeptide hydrolases (specificity and quaterner strucutre) (Cooperation: RCNS Institute of Enzymology, Proteases group)
- Calmodulin/small molecule complexes (Cooperation: RCNS Institute of Enzymology, Lysophospholipid receptors group)
- Structure and function of dUTPases (Cooperation: RCNS Institute of Enzymology, Genome metabolism group, Technical University)
- Radiation damage of protein crystals (BRC, X-Ray Crystallography Laboratory)
Cooperation in protein crystallography:
- ELTE Biokémiai tanszék (biokemia.elte.hu)
- Természettudományi Kutatóközpont (www.ttk.hu/)
- Biostruct laboratórium (www.biostruct.org)
Publications
International scientific papers: 69
Hungarian scientific papers: 4
Book chapter, e-learning : 2, 1
Patent application: 1
All citations / independent citations: 1580 / 1071
H-index: 22
List of publications: https://m2.mtmt.hu/gui2/?type=authors&mode=browse&sel=10003093
Prime Publications
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Veronika Harmat , Klarissza Domokos , Dóra K. Menyhárd , Anna Palló , Zoltán Szeltner , Ilona Szamosi , Tamás Beke , Gábor Náray-Szabó , László Polgár
Structure and catalysis of acylamonoacyl peptidase: closed and open subunits of a dimer oligopeptidase
Journal of Biological Chemistry 286:1987-1998. PMID: 21084296 | DOI: 10.1074/jbc.M110.169862 (2011) Kivonat -
József Dobó , Veronika Harmat , László Beinrohr , Edina Sebestyén , Péter Závodszky , Péter Gál
MASP-1, a Promiscuous Complement Protease: Structure of Its Catalytic Region Reveals the Basis of Its Broad Specificity
J. Immunol. 183:1207-1214. (2009) Kivonat -
Dóra K. Menyhárd , Anna Kiss-Szemán , Éva Tichy-Rács , Balázs Hornung , Krisztina Rádi , Zoltán Szeltner , Klarissza Domokos , Ilona Szamosi , Gábor Náray-Szabó , László Polgár , Veronika Harmat
A self-compartmentalizing hexamer serine protease from Pyrococcus horikoshii: substrate selection achieved through multimerization
J Biol Chem 288(24):17884-17894. | DOI: 10.1074/jbc.M113.451534 | PMID: 23632025 (2013) Kivonat -
László Beinrohr , Veronika Harmat , József Dobó , Zsolt Lörincz , Péter Gál , Péter Závodszky
C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease
J. Biol. Chem. 282: 21100-21109. (2007) Kivonat -
Anna J. Kiss-Szemán , Pál Stráner , Imre Jákli , Naoki Hosogi , Veronika Harmat , Dóra K. Menyhárd , András Perczel
Cryo-EM structure of acylpeptide hydrolase reveals substrate selection by multimerization and a multi-state serine-protease triad
Chemical Science DOI: 10.1039/d2sc02276a (2022) Kivonat -
Anna J. Kiss-Szemán , Luca Takács , Zoltán Orgován , Pál Stráner , Imre Jákli , Gitta Schlosser , Simonas Masiulis , Veronika Harmat , Dóra K. Menyhárd , András Perczel
A carbapenem antibiotic inhibiting a mammalian serine protease: structure of the acylaminoacyl peptidase–meropenem complex
Chemical Science 13, 14264 - 14276 I DOI: 10.1039/D2SC05520A (2022) Kivonat -
Zsolt Dürvanger , Tünde Juhász , Károly Liliom , Veronika Harmat
Structures of calmodulin–melittin complexes show multiple binding modes lacking classical anchoring interactions
J. Biol. Chem. 299(4): 104596 I DOI: 10.1016/j.jbc.2023.104596 (2023) Kivonat
Awards
- 2006, Young Scientist Award of the Hungarian Academy of Sciences
- 2001-2004, Bolyai János Research Fellowship