Amyloidogenic proteins contain short segments (amyloid prone regions) that nucleate formation of large sandwiched β-sheet structures. Analysis of structural properties of interfaces formed between the interacting β-sheets of these oligopeptides is...
In a recent article, we investigated the spontaneous isomerization reaction of peptides containing the asparagine-glycine (-NG-) sequence as a function of pH, temperature and chemical composition (Ac-NGXA-NH2 (X = K(+): lysine, R(+): arginine, A:...
Led by András Perczel, the group has been awarded a 2-year research grant from Richter Gedeon Nyrt. to investigate the potential reversibility of clinically relevant amyloid fibres.
In our article we developed a new technique for the comparison of amino acid environments in protein structures, using the chemical information contained within.
A peptide synthesis method based on flow chemistry developed in our group has enabled the rapid and cost-effective production of small protein domains.
Helga Tar-Pálfi was awarded the Eötvös Day Lecturer Award at the 2024 ELTE Faculty of Chemistry Student Conference 2024. Congratulations to Helga!
We developed anti-SARS-CoV-2 nanobody mutants using in silico techniques, including machine learning approaches and molecular simulations.
