Pseudoproline derivatives, like Thr(ΨPro)-OH, are utilized in peptide synthesis to minimize peptide aggregation and aspartimide formation, but they may induce notable side reactions, particularly under elevated temperature and pressure.This study...

The study uncovers an anomaly in the acid-catalyzed hydrolysis of the 5,6-O-isopropylidene group in specific D-gluco- and D-allofuranose derivatives, linked to C3-epimers with 3-O-imidazole sulfonyl moieties. Advanced modeling reveals how...

Cyclodextrins, particularly OH-free β-CyD, significantly reduce peptide aggregation during SPPS, enhancing the synthesis of challenging peptides like amyloid β (1-42). This innovative approach improves crude peptide purity by 8%-19%, offering an...

This article investigates the efficiency of covalent drugs on the oncogenic protein KRasG12C. Different molecular modifications were used to understand the role of non-covalent and covalent interactions in inhibition. Our results show that the...